What is EBV VCA IgA positive?
A positive serum IgA VCA titer indicates previous repeated infection by the virus or frequent reactivation of latent EBV in B cells. This has been used as a screening tool to identify subjects at high risk of NPC,4,5 as well as being a diagnostic criteria for undifferentiated NPC.
What does it mean if your EBV AB VCA IgG is high?
In general, rising VCA-IgG levels tend to indicate an active EBV infection, while falling concentrations tend to indicate a recent EBV infection that is resolving.
What is the role of EBNA1 in EBV?
Endemic variants of EBNA1 play a significant role in EBV-driven carcinogenesis by altering key regulatory interactions that destabilize latent infection. Epstein-Barr Virus EBNA1 bound to host genes of high significance for B-cell growth and function, including MEF2B, IL6R, and EBF1.
When do EBV nuclear antigen Ab, IgG ( EBNA )?
on What is EBV Nuclear Antigen Ab, IgG (EBNA)? What is EBV Ab VCA, IgM? The EBV (Epstein Barr) Nuclear Antigen Antibodies, IgG test looks for a type of antibody which the body typically develops in response to Epstein-Barr Virus. EBNA antibodies usually appear 2-4 months after infection and persist for the life of the person.
Which is better for NPC, EBV DNA or EBNA1 Iga?
EBV-DNA, VCA-IgA, EBNA1-IgA and Rta-IgG detection have high accuracy in early diagnosis NPC. In addition, EBV-DNA detection has the higher diagnosis accuracy in NPC. On the other hand, EA-IgA is suitable for the diagnosis but not NPC screening.
Where does EBNA1 bind in the human genome?
EBNA1 binds specifically to many sites in the human genome and may regulate some cellular genes in infected cells. [review] These findings highlight a previously unrecognized property of the interaction of EBNA1 with cellular chromatin that may fine-tune its function in the maintenance of viral latency.