How do you inject spectinomycin?
Inject 5 mL intramuscularly for a 2-gram dose. This is also the recommended dose for patients being treated after failure of previous antibiotic therapy. In geographic areas where antibiotic resistance is known to be prevalent, initial treatment with 4 grams (10 mL) intramuscularly is preferred.
What is spectinomycin used to treat?
Trobicin (spectinomycin) For Injectable Suspension is an antibiotic used to treat gonorrhea. Common side effects of Trobicin include nausea, dizziness, soreness at the injection site, hives, insomnia, chills, and fever.
What does spectinomycin treat in dogs?
It is used in human medicine for the treatment of uncomplicated gonorrhoea. In veterinary medicine spectinomycin is used therapeutically for bacterial respiratory and enteric infections.
Is spectinomycin an aminoglycoside?
Spectinomycin is an aminocyclitol antibiotic, which shares similar features with an aminoglycoside. However, it differs in that it does not contain amino sugars or glycosidic bonds. It has a broad spectrum of activity.
What is spectinomycin resistance?
Spectinomycin is an aminocyclitol antibiotic which inhibits bacterial protein biosynthesis by reversibly binding to the 30S ribosomal subunit. Resistance to spectinomycin is commonly due to enzymes which inactivate the drug by adenylylation.
Is E coli resistant to spectinomycin?
Spontaneous mutations to spectinomycin resistance occur in E. coli K-12 at a rate of about 2 x 10(-10). Resistance is transducible with a discrete lag in phenotypic expression, and the kinetics of its development is about the same as that for streptomycin resistance.
Is spectinomycin the same as streptomycin?
Spectinomycin can also be substituted for streptomycin in some cases, and provides more stability, but when increased stability is not required, streptomycin should be used since it is much more cost effective.
Is spectinomycin safe for dogs?
It was well tolerated when administered orally to rats and dogs at doses up to 300 mg/kg/day for up to one year. Parenteral administration of 60 mg/kg/day for 30 days produced no evidence of toxicosis detectable at necropsy.
What class of antibiotic is spectinomycin?
It is in aminocyclitol class, closely related to the aminoglycosides. Spectinomycin is industrially produced by fermentation of the bacterium Streptomyces spectabilis. Spectinomycin is produced in nature by many organisms including cyanobacteria and various plant species.
What is the mechanism of action of spectinomycin?
Mechanism of action Spectinomycin binds to the 30S subunit of the bacterial ribosome and interrupts protein synthesis. One form of resistance has emerged in the 16S ribosomal RNA in Pasteurella multocida.
Can I use streptomycin instead of spectinomycin?
How much lincomycin Can you give a dog?
Oral: 10 mg per pound of body weight every 12 hours or 7 mg per pound every 8 hours. Intramuscular: 10 mg per pound of body weight once a day or 5 mg per pound every 12 hours.