What is Cisatracurium besylate used for?
Nimbex (cisatracurium besylate) is a skeletal muscle relaxant given before general anesthesia in preparation for surgery. Nimbex helps keep the body still during surgery. Nimbex also relaxes the throat so a breathing tube can be more easily inserted before surgery.
What class of drug is Cisatracurium besylate?
Nimbex belongs to a class of drugs called Neuromuscular Blockers, Nondepolarizing. It is not known if Nimbex is safe and effective in children younger than 1 month of age.
What is the difference between atracurium and Cisatracurium?
The same dose (2×ED95 dose) atracurium is more effective neuromuscular blocking agent than cisatracurium, while higher doses of cisatracurium 4×ED95 and 6×ED95 provide more effective, more rapid neuromuscular blocking with longer duration of action, stable hemodynamic status, and no associated signs of histamine …
How long can you stay on NIMBEX?
The rate of spontaneous recovery of neuromuscular function after infusion is independent of the duration of infusion and comparable to the rate of recovery following initial doses (Table 1). Long-term infusion (up to 6 days) of NIMBEX during mechanical ventilation in the ICU has been evaluated in two studies.
What class of drug is rocuronium?
Zemuron belongs to a class of drugs called Neuromuscular Blockers, Nondepolarizing.
How long does rocuronium take to wear off?
Rocuronium is an intermediate-acting nondepolarizing neuromuscular blocker with ED95 of 0.3 mg/kg. At a dosing range of 0.6 to 1.2 mg/kg, intubating conditions can be reached in 1 to 2 minutes, with effects lasting until 20 to 35 minutes.
How long does atracurium last?
It is given by injection into a vein. Effects are greatest at about 4 minutes and last for up to an hour. Common side effects include flushing of the skin and low blood pressure.
Can Cisatracurium be reversed?
Cisatracurium binds to cholinergic receptors on the motor end-plate to antagonise the action of acetylcholine, resulting in a competitive block of neuromuscular transmission. This action is readily reversed by anti-cholinesterase agents such as neostigmine or edrophonium.
What do neuromuscular blocking agents do?
Neuromuscular blocking agents (NMBAs) paralyze skeletal muscles by blocking the transmission of nerve impulses at the myoneural junction.
Can Nurses push nimbex?
May be administered IV direct or by IV infusion by a nurse in Adult Critical Care providing that the patient is receiving full mechanical ventilation. A nurse in Adult Critical Care may administer the initial dose.
What is the reversal agent for nimbex?
What is the pH of cisatracurium besylate injection?
Cisatracurium Besylate Injection, USP is a sterile, non-pyrogenic aqueous solution provided in 5 mL, 10 mL, and 20 mL vials. The pH is adjusted to 3.25 to 3.65 with benzenesulfonic acid. The 5 mL and 10 mL vials each contain cisatracurium besylate, equivalent to 2 mg/mL cisatracurium.
How does cisatracurium besylate work in the skeletal system?
Cisatracurium Besylate is a non-depolarizing skeletal muscle relaxant of the benzylisoquinolinium class. Cisatracurium besylate acts as a competitive acetylcholine antagonist that binds to nicotinic receptors at the neuromuscular junction. Compared to other neuromuscular blocking agents, it is intermediate in its onset and duration of action.
What is the difference between cisatracurium besylate and USP?
Cisatracurium Besylate Injection, USP is a non-depolarizing skeletal muscle relaxant for intravenous administration. Compared to other neuromuscular blocking agents, it is intermediate in its onset and duration of action. Cisatracurium besylate is one of 10 isomers of atracurium besylate and constitutes approximately 15% of that mixture.
What kind of benzyl alcohol is in cisatracurium besylate?
ICU use only, contains cisatracurium besylate, equivalent to 10 mg/mL cisatracurium. The 10 mL vial, intended for multiple-dose use, contains 0.9% benzyl alcohol as a preservative. The 5 mL and 20 mL vials are single-use vials and do not contain benzyl alcohol.