Who needs HLA matched blood?
HLA-matched platelets are indicated for patients that have thrombocytopenia and have demonstrated CCI values consistent with immune refractory thrombocytopenia on at least two occasions.
In which transplants are matching HLA most important?
HLA matching has had the greatest clinical impact in kidney and bone marrow transplantation, where efforts are made to match at the HLA-A, -B, and -DR loci.
What is the best HLA match?
Fully HLA Matched Sibling The recipient and selected sibling donor should be a 6/6 match at HLA-A, -B and -DRB1. In the absence of family typing to establish familial haplotypes, high resolution typing by DNA based methods should be performed and the recipient and donor fully matched at HLA-A, -B, -C, and -DRB1.
How do you test for HLA?
How HLA testing is done. A sample of blood is taken by inserting a needle into a vein in your arm. Sometimes a swab of cells is taken from inside of your cheek (called a buccal swab) for testing. No special preparation is needed for either method.
How is HLA matching done?
How does matching happen? You and potential donors will have blood drawn or will have the inside of your cheek swabbed. The blood or cheek swab is tested in a lab to figure out your HLA type. Your HLA type will be compared to potential donors to see if there is a match.
What is HLA haplotype?
An HLA haplotype is a series of HLA “genes” (loci-alleles) by chromosome, one passed from the mother and one from the father.
Which is the best HLA match for transfusion?
Grade A matches (4 antigen match) are the best but often are not available. Different institutions have different policies on acceptable HLA-Match grades for transfusion and can be discussed with your institution’s blood bank physician.
How are HLA antigens matched on a platelet?
HLA-matching is based on matching the A & B loci of HLA Class I antigens since these represent the predominant HLA antigens present on platelets. HLA matching is graded into 7 categories based on the number of matches.
Is the Red Cross accredited for HLA testing?
Red Cross HLA laboratories are CLIA-certified and accredited by agencies such as the American Society for Histocompatibility and Immunogenetics (ASHI), the United Network of Organ Sharing, the National Marrow Donor Program (NMDP), the New York Department of Health, and the Florida Health Agency. HLA services include:
How does HLA test for leukocyte antigen?
Human Leukocyte Antigen Testing. HLA laboratories also provide DNA based typing for genetic polymorphisms of cytokine genes, minor histocompatibility antigens and natural killer cell immunoglobulin-like receptor (KIR) genes, and for post-HCT engraftment monitoring using short tandem repeat (STR) markers.