What does combinatorial control mean in biology?
[‚käm·bə·nə¦tȯr·ē·əl kən′trōl] (cell and molecular biology) Control of gene expression requiring presence or absence of a particular combination of regulatory proteins.
What is combinatorial control of transcription?
Most importantly is the idea of combinatorial control, which is that any given gene is likely controlled by a specific combination of factors to control transcription. In a hypothetical example, the factors A and B might regulate a distinct set of genes from the combination of factors A and C.
What is combinatorial control of gene expression in animals?
In eukaryotes, regulation of gene expression by transcription factors is said to be combinatorial, in that it requires the coordinated interactions of multiple proteins (in contrast to prokaryotes, in which a single protein is usually all that is required).
What are the two components of the core promoter?
The core promoter comprises DNA sequence elements such as the TATA box, initiator (Inr), motif ten element (MTE), and downstream core promoter element (DPE) (Extended Data Fig. 1a). Each of these motifs is present only at a subset of core promoters. Hence, there are no universal core promoter elements.
What is an advantage of using combinatorial control over eukaryotic genes?
Since each gene is under the control of more than one type and number of cis-regulatory elements, a combinatorial regulation enables the organism to have innumerable expression patterns even with a limited number of transcription factors.
What is a promoter and what does it do?
A promoter is a sequence of DNA needed to turn a gene on or off. The process of transcription is initiated at the promoter. Usually found near the beginning of a gene, the promoter has a binding site for the enzyme used to make a messenger RNA (mRNA) molecule.
What is an example of combinatorial control?
For example, the human genome has about 20,000–25,000 genes. Since each gene is under the control of more than one type and number of cis-regulatory elements, a combinatorial regulation enables the organism to have innumerable expression patterns even with a limited number of transcription factors.
What advantage S can you see in using a combinatorial code to regulate gene expression rather than a single transcription factor for each gene?
Is promoter upstream or downstream?
A promoter is a region of DNA that generally is located upstream of a gene and facilitates and regulates its transcription.
What is the difference between prokaryotic and eukaryotic gene regulation?
Prokaryotic transcription and translation occur simultaneously in the cytoplasm, and regulation occurs at the transcriptional level. Eukaryotic gene expression is regulated during transcription and RNA processing, which take place in the nucleus, and during protein translation, which takes place in the cytoplasm.