What is the most common adverse effect of zidovudine?
The most commonly reported adverse reactions were anemia (hemoglobin less than 9.0 g per dL) and neutropenia (less than 1,000 cells per mm³). Anemia occurred in 22% of the neonates who received RETROVIR and in 12% of the neonates who received placebo.
What are the side effects of zidovudine?
Zidovudine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- stomach pain or cramps.
- heartburn.
- diarrhea (especially in children)
- constipation.
- headache.
- difficulty falling asleep or staying asleep.
How zidovudine can be synthesized?
Zidovudine is an analog of thymidine that inhibits replication of the AIDS virus. It also turned into mono-, di-, and triphosphates by the same cellular enzymes that catalyze phosphorylation of thymidine and thymidine nucleosides.
What is adverse effect of AZT?
The most common side effects of AZT can include headache, nausea, and loss of appetite. More rarely, it can cause anemia and low white blood cell counts. It is usually taken at a dose of 300 mg twice daily, with or without food.
Which antiviral drug causes lipodystrophy as a major adverse effect?
Older kinds of drugs to treat HIV like stavudine (d4T, Zerit), zidovudine (AZT, Retrovir), and some of the older protease inhibitors, like indinavir (Crixivan) have been linked to lipodystrophy. The longer you have taken them, the greater your risk seems to be.
Is zidovudine safe in pregnancy?
Zidovudine was well tolerated by mothers and infants; there was no difference in pregnancy-related side effects between the treatment groups.
Which clients are at risk for severe side effects of nevirapine?
Women, including pregnant women, or patients with higher CD4+ cell counts are at higher risk of hepatotoxicity. Permanently discontinue nevirapine following severe hepatic, skin, or hypersensitivity reactions.
Can antivirals cause psychosis?
They may cause significant neuropsychiatric complications, which range from mild symptoms such as irritability and difficulty sleeping to severe complications such as depression, psychosis, and painful peripheral neuropathy, side effects which may necessitate discontinuation of treatment.
Are there any side effects to taking zidovudine?
It is sold both by itself and together as lamivudine/zidovudine and abacavir/lamivudine/zidovudine. It can be used by mouth or by slow injection into a vein. Common side effects include headaches, fever, and nausea. Serious side effects include liver problems, muscle damage, and high blood lactate levels.
What happens when Alemtuzumab is combined with zidovudine?
Alectinib may decrease the excretion rate of Zidovudine which could result in a higher serum level. The risk or severity of adverse effects can be increased when Alefacept is combined with Zidovudine. The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Zidovudine.
What is the mechanism of action of zidovudine?
Zidovudine is a Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of zidovudine is as a Nucleoside Reverse Transcriptase Inhibitor.
What kind of liver injury does zidovudine cause?
Zidovudine is a rare, but well established cause of clinically apparent acute and chronic liver injury. Zidovudine is a pyrimidine 2′,3′-dideoxyribonucleoside compound having a 3′-azido substituent and thymine as the nucleobase.