How do you administer IV imipenem?
Recommend that the maximum total daily dosage not exceed 4 g/day. Administer 500 mg by intravenous infusion over 20 to 30 minutes. Administer 1000 mg by intravenous infusion over 40 to 60 minutes.
What are the adverse effects of imipenem cilastatin?
Swelling, redness, pain, or soreness at the injection site may occur. This medication may also rarely cause upset stomach, nausea, vomiting, or diarrhea. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
What is the action of imipenem?
Mechanism of action Imipenem inhibits bacterial cell-wall synthesis by binding to penicillin-binding proteins; cilastatin prevents renal metabolism of imipenem.
Why imipenem is given with cilastatin?
The use of a fixed combination of imipenem and cilastatin is motivated by the increases in urinary recovery of imipenem with the combination and by the elimination of the nephrotoxic potential associated with the administration of imipenem alone.
What is cilastatin used for?
Imipenem and cilastatin injection is used to treat certain serious infections that are caused by bacteria, including endocarditis (infection of the heart lining and valves) and respiratory tract (including pneumonia), urinary tract, abdominal (stomach area), gynecological, blood, skin, bone, and joint infections.
What is the purpose of the cilastatin?
What is imipenem cilastatin used for?
IMIPENEM; CILASTATIN (i mi PEN em; sye la STAT in) is a carbapenem antibiotic. It is used to treat certain kinds of bacterial infections. It will not work for colds, flu, or other viral infections.
What does cilastatin do for imipenem?
Cilastatin is in a class of medications called dehydropeptidase inhibitors. It works by helping imipenem stay active in your body for a longer period of time. Antibiotics such as imipenem and cilastatin injection will not work for colds, flu, or other viral infections.
Why imipenem is combined with cilastatin?
Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase. Renal Dehydropeptidase degrades the antibiotic imipenem. Cilastatin is therefore combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect.