What is the Uveoscleral drainage?
Share: The term uveoscleral outflow refers to the drainage of ocular aqueous humor from the anterior chamber into the anterior chamber angle other than through the trabecular meshwork (Figure). Unlike the trabecular outflow route, the uveoscleral outflow route is not a distinctive pathway with tubes and channels.
Does pilocarpine increase Uveoscleral outflow?
The uveoscleral outflow is decreased by contraction (pilocarpine) and increased by relaxation (atropine) of the ciliary muscle. Thus, changing the tone of the ciliary muscle may redistribute aqueous humour between the conventional and uveoscleral outflow routes.
What is the purpose of trabecular meshwork?
The trabecular meshwork, located within the iridocorneal angle, is the main pathway for drainage of aqueous humor (AH) out of the eye, and its dysfunction is responsible for the IOP elevation.
What is trabecular outflow?
The trabecular outflow pathway is the primary draining tissue for the aqueous humor in the eye. It consists of 3 structures, the trabecular meshwork (TM), juxtacanalicular tissue, and Schlemm’s canal. In a healthy eye, IOP is maintained within a narrow range through dynamic regulation of trabecular outflow resistance.
How does Latanoprost increase Uveoscleral outflow?
The known effect of Latanoprost increase uveoscleral outflow by remodeling extracellular matrix and widening intermuscular spaces in the ciliary body may not detected by pneumotonography after 2 weeks of treatment.
How does prostaglandin increase Uveoscleral outflow?
Prostaglandins decrease the intraocular pressure by increasing the uveoscleral outflow. Two mechanisms seem to contribute to this effect: relaxation of the ciliary muscle and changes in extracellular matrix, causing decreased resistance in the uveoscleral outflow routes.
What blocks the trabecular meshwork in glaucoma?
Pigment dispersion, where tiny fragments or granules from the iris (the colored part of the eye) can circulate in the aqueous humor (the fluid within the front portion of the eye) and block the trabecular meshwork, the tiny drain for the eye’s aqueous humor.
What happens when trabecular meshwork is blocked?
Angle-closure glaucoma occurs when the iris is positioned against the trabecular meshwork, blocking the flow of aqueous out of the eye and raising the intraocular pressure. When this occurs acutely, the pressure can be very high. The patient has pain and often nausea and vomiting.
What are the two natural aqueous outflow pathways?
Aqueous humor outflow occurs through two routes, the conventional and uveoscleral pathways.