What does acid phosphatase do in the prostate?
Although prostatic acid phosphatase is a fairly nonspecific enzyme in vitro, there is substantial circumstantial evidence that this protein plays a role in regulating levels of protein phosphorylation, particularly on tyrosine.
Why is acid phosphatase high in prostate?
Prostatic acid phosphatase (PAP), which is produced in the prostate, was the first major serum marker for prostate cancer. Metastasis of prostate cancer beyond the capsule, particularly to the bone, causes a rise in acid phosphatase level, with the level increasing in correspondence to the extent of the disease.
Does the prostate secrete acid phosphatase?
Acid phosphatase (ACP) is synthesized in the prostate under androgen control. It is present in human seminal plasma at levels 100–1000× higher than in any other body fluid.
Where in the male reproductive tract is acid phosphatase produced?
Prostatic acid phosphatase (PAP) is an enzyme produced by the prostate.
What are the substrate used in the determination of total acid phosphatase and prostatic acid phosphatase?
During the selection of a substrate for determination of acid phosphatase, Labtest have focused on monophosphate thymolphthalein research, that posses more specificity to prostatic isoenzymes than the phenyl phosphate and p-nitro phenyl phosphate. After dissolved, it contains monophosphate thymolphthalein (1.5 mmol/L).
What does an elevated PAP prostatic acid phosphatase imply?
Prostatic acid phosphatase (PAP) originates in the prostate and is normally present in small amounts in the blood. In addition to prostate cancer, elevated levels of PAP may indicate testicular cancer, leukemia, and non-Hodgkin’s lymphoma, as well as some noncancerous conditions.
What is human prostatic acid phosphatase?
Prostatic acid phosphatase (PAP), also prostatic specific acid phosphatase (PSAP), is an enzyme produced by the prostate. It may be found in increased amounts in men who have prostate cancer or other diseases. The highest levels of acid phosphatase are found in metastasized prostate cancer.
What is the role of acid phosphatase?
Acid phosphatase is a ubiquitous lysosomal enzyme that hydrolyses organic phosphates at an acid pH. Although the postpuberteral prostatic epithelial cell contains a uniquely high concentration of acid phosphatase, cellular components of bone, spleen, kidney, liver, intestine, and blood also contain this enzyme.
Is prostatic fluid alkaline or acidic?
Prostatic fluid is generally acidic, with a pH of 6.4 (compared with plasma pH of 7.4), thus creating a pH gradient that further inhibits diffusion of acidic antibiotics into the prostatic fluid.
What is the function of the prostate in a man?
The prostate gland is located just below the bladder in men and surrounds the top portion of the tube that drains urine from the bladder (urethra). The prostate’s primary function is to produce the fluid that nourishes and transports sperm (seminal fluid).
What is the principle of acid phosphatase test?
The enzyme acid phosphatase hydrolyses the substrate to the corresponding phenol and phosphate ion. The phenol formed is simultaneously coupled with a suitable diazonium salt as a chromogen to give a characteristic colored dye stuff, which is a positive test for the presence of a seminal stain.