Why STAT3 is a unique target for cancer therapy?
Besides its canonical function as transcription factor, STAT3 plays a distinct role in the mitochondria, where it supports Ras-dependent malignant transformation [107], promotes autophagy, and restrains ROS levels, thus increasing cancer cell survival [108].
Is STAT3 an oncogene?
Signal transducers and activators of transcription (STAT) proteins are a family of transcription factors first characterized for their role in cytokine signaling.
What is STAT3 function?
Through its regulation of gene activity, the STAT3 protein is involved in many cellular functions. It helps control cell growth and division (proliferation), cell movement (migration), and the self-destruction of cells (apoptosis). The STAT3 protein is active in tissues throughout the body.
What does STAT3 induce?
STAT3 signaling within the tumor microenvironment induces a procarcinogenic cytokine, IL-23, via direct transcriptional activation of the IL-23/p19 gene in tumor-associated macrophages, while inhibiting a central anticarcinogenic cytokine, IL-12, thereby shifting the balance of tumor immunity toward carcinogenesis.
What chromosome is STAT3 on?
| STAT3 | ||
|---|---|---|
| Location (UCSC) | Chr 17: 42.31 – 42.39 Mb | Chr 11: 100.89 – 100.94 Mb |
| PubMed search | ||
| Wikidata | ||
| View/Edit Human View/Edit Mouse |
What is the function of STAT3?
Through its regulation of gene activity, the STAT3 protein is involved in many cellular functions. It helps control cell growth and division (proliferation), cell movement (migration), and the self-destruction of cells (apoptosis).
What is the STAT3 gene?
The STAT3 gene is part of a family known as the STAT genes. These genes provide instructions for making proteins that are part of essential chemical signaling pathways within cells.