What is Paracetamol ratiopharm used for?
Paracetamol, the active substance of Paracetamol-ratiopharm, has a pain and fever-relieving effect.
Is paracetamol a cyclooxygenase inhibitor?
Paracetamol is termed a simple analgesic and an antipyretic. Despite enduring assertions that it acts by inhibition of cyclooxygenase (COX)- mediated production of prostaglandins, unlike non-steroidal anti-inflammatory drugs (NSAIDs), paracetamol has been demonstrated not to reduce tissue inflammation.
What is the mechanism of paracetamol in controlling fever?
Paracetamol reduces fever by affecting an area of the brain that regulates our body temperature (the hypothalamic heat-regulating center). Paracetamol is about as effective as aspirin and ibuprofen at relieving mild to moderate pain and reducing fever, but unlike these it doesn’t reduce inflammation.
What happens if you take 1000mg paracetamol?
An overdose of paracetamol can cause serious harm. The maximum amount of paracetamol for adults is 1 gram (1000 mg) per dose and 4 grams (4000 mg) per day. Taking more paracetamol could cause damage to your liver.
What type of inhibitor is in paracetamol?
Paracetamol (acetaminophen) is generally considered to be a weak inhibitor of the synthesis of prostaglandins (PGs). However, the in vivo effects of paracetamol are similar to those of the selective cyclooxygenase-2 (COX-2) inhibitors.
Why is paracetamol a weak COX inhibitor?
Therefore, paracetamol and salicylate may selectively inhibit PG synthesis involving COX-2 because the lower flux through this pathway produces lesser levels of the hydroperoxide, PGG2, than the pathway involving COX-1.
What is COX-1 and COX-2?
The enzymes that produce prostaglandins are called cyclooxygenase (COX). There are two types of COX enzymes, COX-1 and COX-2. Both enzymes produce prostaglandins that promote inflammation, pain, and fever; however, only COX-1 produces prostaglandins that activate platelets and protect the stomach and intestinal lining.
How does aspirin work COX?
Aspirin inhibits COX-1 (cyclooxygenase-1). Its effect on COX-2 is more delicate: it “turns off” COX-2’s production of prostaglandins but “switches on” the enzyme’s ability to produce novel protective lipid mediators. Aspirin is a widely used non-steroidal anti-inflammatory drug (NSAID).