Which CSF may be prescribed to treat neutropenia?
A G-CSF is a drug that doctors prescribe for treating neutropenia. Neutropenia is a condition that causes a person’s white blood cell level to drop below normal. White blood cells can drop in people with some types of cancer and those taking certain medications, such as chemotherapy.
What is G-CSF for neutropenia?
A drug used under the brand names Neupogen, Zarxio, and Nivestym to treat neutropenia (a lower-than-normal number of white blood cells), prevent infection, and prepare the blood for the collection of certain types of blood cells, and under the brand name Granix to treat neutropenia.
Is filgrastim used for neutropenia?
Filgrastim is capable of reducing the incidence and severity of neutropenia and the complications that accompany it in patients with cancer or HIV infection.
What is the primary effect of G-CSF administration on the circulating white blood cell count differential?
G-CSF treatment caused rapid and large but transient increases in the number of circulating CD34+ cells, colony-forming cells, and long-term culture-initiating cells and in the short-term repopulating activity detectable in nonobese diabetic/severe combined immunodeficiency/β2-microglobulin-null mice.
When is G-CSF administered?
With chemotherapy G-CSF is usually started 24 hours or more after your chemotherapy finishes. You usually have it daily. Your doctor or pharmacist will tell you how many injections you need. Some types of G-CSF stay in the body for longer.
What is G-CSF and GM-CSF?
G-CSF and GM-CSF are used widely to promote the production of granulocytes or APCs. The U.S. Food and Drug Administration approved G-CSF (filgrastim) for the treatment of congenital and acquired neutropenias and for mobilization of peripheral hematopoietic progenitor cells for stem cell transplantation.
When is G-CSF given?
What is another name for filgrastim?
Neupogen, Granix and Zarxio are trade names for filgrastim. Granulocyte – colony stimulating factor (G-CSF) is another name for filgrastim. In some cases, health care professionals may use the trade name Neupogen, Granix or Zarxio when referring to the generic drug name filgrastim.
Does G-CSF increased neutrophils?
During the course of an infection, serum levels of G-CSF increase which in turn enhances proliferation of granulocytic precursor cells and an increased level of circulating neutrophils (23).
When should you not give G-CSF?
GCSF should not be administered within 24 hours of cytotoxic chemotherapy- therefore start at least 24 hours after the completion of chemotherapy and stop at least 24 hours before next chemotherapy due.