Is CD44 a stem cell marker?
CD44 is a compelling marker for cancer stem cells of many solid malignancies. In addition, interaction of HA and CD44 promotes EGFR-mediated pathways, consequently leading to tumor cell growth, tumor cell migration, and chemotherapy resistance in solid cancers.
What is the function of CD44?
The cell-surface glycoprotein CD44 is involved in a multitude of important physiological functions including cell proliferation, adhesion, migration, hematopoiesis, and lymphocyte activation.
What is CD44 a marker of?
CD44 cleavage, shedding, and elevated levels of soluble CD44 in the serum of patients is a marker of tumor burden and metastasis in several cancers including colon and gastric cancer. Recent observations have shown that CD44 intracellular domain (CD44-ICD) is related to the metastatic potential of breast cancer cells.
Which cells have CD44?
Distribution. Standard CD44 (Figure 1) is a ubiquitous molecule expressed on many types of cells of lymphohematopoietic origin, including erythrocytes, T and B lymphocytes, natural killer cells, macrophages, Kupffer cells, dendritic cells and granulocytes.
Do T cells express CD44?
CD44 is a type I transmembrane glycoprotein and expressed by many different cell types. CD44 is one of the most commonly used activation markers for T cells. After antigen encounter, T cells rapidly up-regulate CD44 and its expression is also maintained in memory T cells [6].
What does CD44 stand for?
CD44, a non-kinase transmembrane proteoglycan, is a single-chain glycoprotein encoded by one gene located on chromosome 11 in humans and on chromosome 2 in mice. The CD44 gene is comprised of 19 exons in humans and 20 in mice; a homolog of exon 6 or variant 1 is not found in humans [19].
Is CD44 a protein?
CD44 (CD44 Molecule (Indian Blood Group)) is a Protein Coding gene. Diseases associated with CD44 include Superficial Keratitis and Intraductal Papilloma. Among its related pathways are Integrin cell surface interactions and Interferon gamma signaling.
Do B cells express CD44?
Standard CD44 (Figure 1) is a ubiquitous molecule expressed on many types of cells of lymphohematopoietic origin, including erythrocytes, T and B lymphocytes, natural killer cells, macrophages, Kupffer cells, dendritic cells and granulocytes.
What is CD44 cell?
What does L selectin bind?
Similar to P-selectin, L-selectin also binds to sulfatides and sulfated polysaccharides such as fucoidan and heparin. A group of O-glycosylated mucins decorated with sialic acid, termed sialomucins, represents the protein ligands for L-selectin. They are GlyCAM-1, CD34 and MAdCAM-1.
What are EMT markers?
Cell-surface markers of EMT. A change in expression of E-cadherin is the prototypical epithelial cell marker of EMT. E-cadherin is expressed in epithelial cells, and its expression is decreased during EMT in embryonic development, tissue fibrosis, and cancer (65).