What is lymphocyte stimulation?
The lymphocyte stimulation test (LST) is one of the most useful laboratory tests for the identification of allergy to a specific drug.
What is a mitogen in immunology?
From Wikipedia, the free encyclopedia. A mitogen is a peptide or small protein that induces a cell to begin cell division: mitosis. Mitogenesis is the induction (triggering) of mitosis, typically via a mitogen.
What is the meaning of proliferation of lymphocytes?
Definition. Lymphocyte proliferation is defined as the process whereby lymphocytes begin to synthesize DNA after cross-linking of their antigen receptor either following recognition of antigen or stimulation by a polyclonal activator (mitogen).
What is T cell blastogenesis?
Upon activation of a cognate T-cell receptor (TCR), the cell enlarges in a process termed blastogenic transformation, or blastogenesis. This process is detectable in the first ~6 hr after the stimulus is applied1. During blastogenesis, the volumes of individual T cells increase 2- to 4-fold2-6.
What is mitogen lab?
Precision Diagnostics Mitogen supports accurate immune system diagnostics by utilizing advanced technology platforms for the most comprehensive detection of autoantibodies, cytokines, and other related biomarkers. Requisition Forms.
What is a mitogen test for?
This test measures lymphocyte proliferation in response to stimulation with nonspecific mitogens phytohemagglutinin (PHA), concanavalin A (Con A), and pokeweed mitogen (PWM); and T lymphocyte proliferation in response to stimulation with recall antigens tetanus toxoid and Candida, determined by flow cytometry.
What is mitogen stimulation?
Mitogens are non-specific stimulants of immune cells. Mitogen stimulation leads to immune cell activation and is used as a measure of general immune function. However, immune cells that respond to mitogens may not respond to other antigens.
What is a mitogen test?
86353 – Lymphocyte transformation, mitogen or antigen induced. blastogenesis. Test Includes: Viability of lymphocytes to help determine impaired T-cell function. Peripheral blood mononuclear cells (PBMC) are cultured in vitro with plant lectins (mitogens) such as phytohemagglutinin (PHA) and pokeweed mitogen (PWM).
Why do lymphocytes proliferate?
Lymphocyte proliferation is the first step in a proper immune response to create effector lymphocytes, necessary to eliminate a current antigen, or memory lymphocytes, necessary to eliminate the same antigen the host may encounter in the future; this memory function insures that future responses to an antigen are …
What is lymphocyte blastogenesis?
Activation is accompanied by morphologic changes known as lymphocyte transformation, in which small, resting lymphocytes are transformed into large, active lymphocytes (lymphoblasts); the formation of lymphoblasts is referred to as blastogenesis.
What is a mitogen stimulation test for?
Mitogen-stimulated immune responses serve as a positive control reaction in tests to measure antiviral immune cell function. Healthy immune cells respond to stimulation with mitogens.
What is mitogen blood test?