Does valproate cause liver damage?
Valproic acid may cause serious or life-threatening damage to the liver that is most likely to occur within the first 6 months of therapy.
Does valproic acid increase liver enzymes?
Moreover, Spiller et al. (2000) reported that valproic acid mediated hepatic injury is associated with dose dependent rise in serum liver enzymes.
Does epilim affect the liver?
Medicines used in the treatment of epilepsy, including Epilim may have adverse effects on the liver and the kidneys. a urea cycle disorder or a family history of urea cycle disorders.
Does valproic acid cause fatty liver?
Weight gain and obesity have been observed as side effects of VPA. These are often linked with other metabolic disturbances such as development of insulin resistance, dyslipidemia, metabolic syndrome (MetS) and non-alcoholic fatty liver disease or nonalcoholic fatty liver disease (NAFLD).
Can Tegretol damage your liver?
Liver function: Carbamazepine can cause decreased liver function and may cause liver failure.
Can phenytoin affect the liver?
Phenytoin is an anticonvulsant that in rare cases can cause acute idiosyncratic drug-induced liver disease that can be severe or even fatal. The liver injury caused by phenytoin appears to be due to a hypersensitivity reaction and resembles cases of immunoallergic hepatotoxicity.
Does phenytoin affect the liver?
Does carbamazepine damage the liver?
Carbamazepine is an aromatic anticonvulsant that is widely used in therapy of epilepsy and trigeminal neuralgia and is a well established cause of clinically apparent liver injury which can be severe and even fatal.
Can vimpat cause liver damage?
See “What is the most important information I should know about VIMPAT?” VIMPAT may cause other serious side effects including: A serious allergic reaction that may affect your skin or other parts of your body such as your liver or blood cells.
Can Depakote cause cirrhosis of the liver?
A: The following serious side effects are associated with Depakote: Serious liver damage that can cause death, especially in children younger than 2 years old. Risk of serious liver damage is more likely to occur within the first 6 months of treatment, and may continue despite discontinued use of the drug.
Does Depakote cause fatty liver?
Drugs reported to cause fatty liver include total parenteral nutrition, methotrexate (Rheumatrex), griseofulvin (Grifulvin V), tamoxifen (Nolvadex), steroids, valproate (Depakote), and amiodarone (Cordarone). In certain situations, fatty liver alone can be life threatening.
Does carbamazepine cause fatty liver?
Histological findings excluded hepatic porphyria, but revealed severe fatty changes thought to be caused by idiosyncratic metabolism of carbamazepine. While the porphyrinogenicity of carbamazepine is well known, the presence of variegate porphyria has not been reported.