What is the MSH6 gene?
The MSH6 gene provides instructions for making a protein that plays an essential role in repairing DNA. This protein helps fix errors that are made when DNA is copied (DNA replication) in preparation for cell division.
Is MSH6 a tumor suppressor gene?
MSH6 is also a tumor suppressor gene, although inactivation of MSH6 yields a slightly less severe phenotype than that caused by MSH2 or MLH1 mutations because in MSH6-deficient cells, one class of mismatches, insertions/deletions, apparently are repaired normally.
What type of mutation is Lynch syndrome?
Lynch syndrome has an autosomal dominant pattern of inheritance and is caused by a mutation in the MLH1, MSH2, MSH6, PMS2 or EPCAM gene . Treatment of colon cancer is surgical removal of the affected part of the colon (colectomy). People with Lynch syndrome should have routine colonoscopies.
What does MSH6 positive mean?
MSH6 mutation. Your testing shows that you have a pathogenic mutation or a variant that is likely pathogenic in the MSH6 gene. 2. Lynch syndrome. People with MSH6 mutations have Lynch syndrome, previously known as hereditary non-polyposis colorectal cancer (HNPCC).
What chromosome is MSH6 on?
The name MSH6 stands for “MutS homolog 6.” The gene is located on chromosome 2. The MSH6 gene protein plays an important role in repairing DNA damage.
What does MSH6 stand for?
Is HER2 a tumor suppressor gene?
In vivo studies show that these HER2/neu repressors can act therapeutically as tumor suppressor genes for tumors that overexpress HER2/neu. These preclinical studies clearly indicate that transcriptional repressors that downregulate HER2/neu can be effective regimens for cancer treatment in a gene therapy format.
What is MSH2 and MSH6?
The MSH2 protein joins with one of two other proteins, MSH6 or MSH3 (each produced from a different gene), to form a two-protein complex called a dimer. This complex identifies locations on the DNA where errors have been made during DNA replication.
What cancers does Lynch syndrome cause?
Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC), is the most common cause of hereditary colorectal (colon) cancer.
- Uterine (endometrial),
- Stomach,
- Liver,
- Kidney,
- Brain, and.
- Certain types of skin cancers.