What is the meaning of interleukin 10?
One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-10 is made by activated macrophages and by some T lymphocytes. It reduces inflammation by blocking production of cytokines by immune cells.
What is interleukin 10 What is its function?
Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that plays a central role in limiting host immune response to pathogens, thereby preventing damage to the host and maintaining normal tissue homeostasis.
What is interleukin mean?
interleukin (IL), any of a group of naturally occurring proteins that mediate communication between cells. Interleukins regulate cell growth, differentiation, and motility. They are particularly important in stimulating immune responses, such as inflammation.
Is IL-10 a Th1 cytokine?
Interleukin-10 (IL-10) is widely known as an immunosuppressive cytokine by virtue of its ability to inhibit macrophage-dependent antigen presentation, T-cell proliferation, and Th1 cytokine secretion.
Who discovered IL-10?
In the late 1980s, Tim Mosmann and colleagues isolated functionally distinct T helper (Th)-1 and Th2 clones, and provided evidence that these two subsets were mutually inhibitory. Knowledge of the inhibition led to the discovery that Th2 cells make IL-10 to suppress Th1 cells.
What is the difference between Interleukin and cytokine?
Interleukins are a group of cytokines that were first seen to be expressed by white blood cells. Cytokines are a broad category of small proteins that are important in cell signaling. Cytokines include chemokines, interferons, interleukins, lymphokines, but generally not hormones or growth factors .
What are the different types of interleukin and their functions?
In humans
| Name | Source | Function |
|---|---|---|
| IL-30 | – | Forms one chain of IL-27 |
| IL-31 | Th2 cells | May play a role in inflammation of the skin |
| IL-32 | – | Induces monocytes and macrophages to secrete TNF-α, IL-8 and CXCL2 |
| IL-33 | epithelial cells | Induces helper T cells to produce type 2 cytokine |
Is IL-10 anti inflammatory?
Interleukin (IL)-10 is a pleiotropic cytokine known for its potent anti-inflammatory and immunosuppressive effects.
Does IL-10 stimulate Th2?
Both DC-derived and T cell–derived IL-10 cells promote the Th2 response and inhibit the Th1 response to antigen in vivo.
What is the function of interleukin 10 in humans?
Interleukin 10. Interleukin 10 ( IL-10 ), also known as human cytokine synthesis inhibitory factor ( CSIF ), is an anti- inflammatory cytokine. In humans, interleukin 10 is encoded by the IL10 gene. IL-10 signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor-2 proteins.
What kind of cytokines can interleukin 10 inhibit?
IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as IFN-γ, IL-2, IL-3, TNFα and GM-CSF made by cells such as macrophages and Th1 T cells.
What are the effects of interleukin-10 mutations?
IL10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Segen’s Medical Dictionary. © 2012 Farlex, Inc. All rights reserved. in·ter·leu·kin-10 (in’tĕr-lū’kin)
How did the term interleukin get its name?
The term ‘interleukin’ was first coined in 1979 in a letter to the editor of the Journal of Immunology to describe a number of secreted molecules produced by leukocytes, a variety of polypeptides that act specifically as mediators between leucocytes.