What does methylmalonic acid test for?
What is it used for? An MMA test is most often used to diagnose a vitamin B12 deficiency. This test is also used to diagnose methylmalonic acidemia, a rare genetic disorder. Symptoms of this disorder can range from mild to severe and may include vomiting, dehydration, developmental delays, and intellectual disability.
Do MMA fighters get tested for drugs?
The program includes a comprehensive drug-testing policy that will incorporate random, year-round unannounced testing of all 600-plus fighters on the UFC’s roster. A minimum of 2,750 tests will take place across the UFC roster each year, which averages out to about five random tests per fighter, per year.
What is a urinary MMA test?
This test measures the amount of a substance called methylmalonic acid (MMA) in your urine. MMA is typically made in tiny amounts when you digest protein. Your body makes large amounts of MMA if you have a decrease in the amount of vitamin B-12. MMA is excreted in your urine.
What drugs do they test for in a urine drug test?
These tests indicate if one or more prescription or illegal drugs are present in urine. These tests detect the presence of drugs such as marijuana, cocaine, opiates, methamphetamine, amphetamines, PCP, benzodiazepine, barbiturates, methadone, tricyclic antidepressants, ecstasy, and oxycodone.
What should your methylmalonic acid levels be?
In general, normal levels of methylmalonic acid are between 0.00 and 0.40 umol/mL (micromoles per milliliter). Although higher levels of methylmalonic acid may be an indication of vitamin B-12 deficiency, elevated levels may not warrant immediate treatment.
What causes high methylmalonic acid?
Causes of high MMA include: B12 deficiency, most often due to a B12-poor diet, issues with nutrient absorption, or drugs that deplete B12 levels (e.g. metformin) [2, 28] Poor kidney function. Kidneys that are not working properly can’t filter MMA into the urine, causing it to accumulate in the blood [3]
Does the UFC test for drugs?
Any athlete competing in a UFC Bout may be subject to testing for all prohibited substances and methods, including those that are prohibited only in-competition.
What causes elevated methylmalonic acid?
Elevated levels of methylmalonic acid (MMA) result from inherited defects of enzymes involved in MMA metabolism or inherited or acquired deficiencies of vitamin B12 (cobalamin) or its downstream metabolites.
How is MMA diagnosed?
Methylmalonic acidemia can be diagnosed through newborn screening . Almost every state in the United States screens for this disorder. Additional testing required for diagnosis may include: Biochemical testing for abnormal levels of specific chemicals.