Which MTHFR gene is worse?
Because each person has two copies of the MTHFR gene , people can inherit one copy of a MTHFR gene variant or two copies of it (one from each parent). People who inherit two copies of C677T have a higher risk for having a child with a neural tube defect.
Can you have both MTHFR mutations?
You can have either one or two mutations — or neither — on the MTHFR gene. These mutations are often called variants. A variant is a part of a gene’s DNA that’s commonly different, or varies, from person to person. Having one variant — heterozygous — is less likely to contribute to health issues.
Can MTHFR cause miscarriage?
Hyperhomocysteinemia is a condition where the homocysteine levels are elevated. Hyperhomocysteinemia is often seen in people with a positive MTHFR mutation gene test. High homocysteine levels, especially with low folic acid levels, can lead to pregnancy complications that include: miscarriage.
What is the difference between MTHFR c1298c and C677T?
MTHFR C1298C = homozygous mutation (two mutations) MTHFR C677T + MTHFR A1298C = a compound heterozygous mutation One of the biggest concerns for those with an MTHFR mutation is the effect it may have on homocysteine levels in the blood.
Are there symptoms for the MTHFR A1298C mutation?
Research seems to ignore it almost completely while the C677T MTHFR mutation gets all the attention and glory. For those who have the A1298C MTHFR mutation, this is frustrating. Symptoms exist and doctors are saying there is no correlation between the MTHFR A1298C mutation and your symptoms – right?
Can a single copy of MTHFR A1298C be harmful?
Again, a single copy of A1298C MTHFR does not appear to be harmful unless it is combined with the C677T MTHFR snp – known as compound heterozygous. For now, I hope this is useful for you and has shed some light into your situation.
How many copies of the MTHFR gene are there?
There are two common MTHFR mutations, known as C677T and A1298C. Having one copy of C677T or one copy of A1298C is not associated with health risks. Likewise, having two copies of A1298C is not associated with significant health risks.