What is metanephrogenic blastema?
Metanephric blastema (or metanephrogenic blastema) is one of the two embryological structure that gives rise to the kidney, the other one being the ureteric bud.
What does the Metanephros give rise to?
The metanephros gives rise to the adult kidney. The permanent kidney begins to form at 5 weeks gestation and becomes functional toward the end of the first trimester. It arises from inductive interactions between the ureteric bud (a mesonephric duct diverticulum) and the metanephric cap (metanephric mesoderm).
What is formed from the ureteric bud?
The ureteric bud (also known as the metanephrogenic diverticulum) is a protrusion of the mesonephric duct that appears during the embryological development of urogenital organs. It will eventually form the urinary collecting system (i.e. collecting tubes, calyces, renal pelvis, ureter) of the kidney.
What is metanephric differentiation?
The early development of the metanephric kidney is characterized by the induced differentiation of mesenchymal cells into a stem cell population that undergoes a mesenchymal to epithelial transformation in response to stimuli from the ureteric bud.
What is derived from the Metanephric Blastema?
GDNF, gonadal derived neurotrophic factor, is produced by the metanephric blastema and is essential in binding to the Ret receptor on the ureteric bud, which bifurcates and coalesces as a result to form the renal pelvis, major and minor calyces and collecting ducts. …
What is renal dysplasia?
Kidney dysplasia is a condition in which the internal structures of one or both of a fetus’ kidneys do not develop normally while in the womb. During normal development, two thin tubes of muscle called ureters grow into the kidneys and branch out to form a network of tiny structures called tubules.
What is a ureteric bud?
The ureteric bud (UB) is an epithelial tube that arises from the nephric duct and branches repetitively to give rise to the renal collecting duct system while also generating inductive signals that promote nephrogenesis by surrounding metanephric mesenchyme (MM) cells.
Is ureteric bud endoderm?
Intermediate mesoderm forms the kidneys, ureters and the vasculature. Splanchnopleuric mesoderm forms the smooth muscle and connective tissue of the bladder. Endoderm forms the bladder and urethra.
What is Mesonephric kidney?
The mesonephric kidney is an embryonic organ that disappears in all mammalian species when the permanent kidney—the metanephros—is functional. The epididymal ducts and the rete ovarii are derived from the mesonephros in adult males and females, respectively.
What is the function of the Metanephric kidney?
The mammalian metanephric kidney is a highly complex organ that filters waste products from the circulation, maintains electrolyte and pH balance of body fluid, bone mineralization, blood pressure and blood composition. Many of these actions are carried out by the nephron: the repeated, functional unit of the kidney.
What is the metanephric mesenchyme?
The metanephric mesenchyme (MM) is one of the two embryonic structures that give rise to the kidney. MM is comprised of mesenchymal cells situated adjacent to the tips of the branching ureteric bud. These cells form the nephrons.
https://www.youtube.com/watch?v=W76SYjJDHwA