What do gonadotropin releasing hormone agonist do?
Gonadotropin releasing hormone agonists (GnRH) are a type of medication that suppresses ovulation by stopping the production of estrogen and progesterone. In order for this axis to function properly and result in ovulation, GnRH has to be released in a pulsatile fashion.
Why would a GnRH agonist be expected to down regulate gonadotropin secretion?
GnRH agonists relieve symptoms of endometriosis by down-regulating GnRH receptors in the hypothalamus and pituitary, thereby reducing gonadotropin and estrogen secretion.
What is the mechanism of action of GnRH agonist?
Prolonged activation of GnRH receptors by GnRH leads to desensitization and consequently to suppressed gonadotrophin secretion. This is the primary mechanism of action of agonistic GnRH analogues.
What is gonadotropin releasing hormone regulated by?
Gonadotropin-releasing hormone (GnRH) is a key regulatory molecule of the hypothalamus–pituitary (PIT)–gonadal (HPG) axis. Neurons in the hypothalamus release GnRH which acts downstream on the PIT to stimulate transcription and secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH) (1).
What are the side effects of gonadotropin releasing hormone agonist?
Common side effects of the GnRH agonists and antagonists include symptoms of hypogonadism such as hot flashes, gynecomastia, fatigue, weight gain, fluid retention, erectile dysfunction and decreased libido. Long term therapy can result in metabolic abnormalities, weight gain, worsening of diabetes and osteoporosis.
What is the function of an agonist?
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response. In contrast, an antagonist blocks the action of the agonist, while an inverse agonist causes an action opposite to that of the agonist.
What are the side effects of gonadotropin releasing hormone GnRH agonists?
How does GnRH agonist decrease testosterone?
GnRH agonists that have been marketed and are available for medical use include buserelin, gonadorelin, goserelin, histrelin, leuprorelin, nafarelin, and triptorelin….Available forms.
| Name | Histrelin |
|---|---|
| Brand names | Vantas; Supprelin LA |
| Approved uses | Precocious puberty; Prostate cancer |
| Routes | Implant |
| Launch | 1993 |
What does Lupron do to the body?
Lupron is a type of hormone therapy for prostate cancer. It works by lowering the amount of testosterone in a person’s body, which helps slow the growth of cancer cells. Doctors often prescribe hormone therapies in combination with radiation therapy or following surgery.