Is benzimidazole acidic or basic?
Benzimidazole is a base: C6H4N(NH)CH + H+ → [C6H4(NH)2CH]
Is benzimidazole aromatic?
ABSTRACT: Benzimidazole is a heterocyclic aromatic organic compound containing nitrogen. This bicyclic compound is formed by the fusion of benzene with imidazole ring.
What is moiety present in benzimidazole?
Benzimidazole moiety is a fusion of benzene and imidazole ring system at the 4 and 5 positions of imidazole ring. They have properties of both acids and bases.
Which is the category of benzimidazole?
This compound belongs to the class of organic compounds known as benzimidazoles. These are organic compounds containing a benzene ring fused to an imidazole ring (five member ring containing a nitrogen atom, 4 carbon atoms, and two double bonds).
Which acid is used in the synthesis of benzimidazole?
boric acid
Synthesis of benzimidazoles has been developed by the o-phenylenediamine with aldehydes using boric acid an efficient catalyst under mild reaction conditions in aqueous media.
Is benzimidazole a heterocyclic compound?
Benzimidazole nucleus is one of the bioactive heterocyclic compounds that exhibit a range of biological activities. Specifically, this nucleus is a constituent of vitamin B12 (O’Neil et al., 2001).
Which are benzimidazole derivatives?
Benzimidazole derivatives, particularly ABZ and MBZ are well known for their anti-Giardia potency, particularly as compared with other drugs used for routine treatment of giardiasis (i.e. lower IC50 against trophozoites in vitro and lower ED50 in experimental infections).
Which of the following is the theoretical yield of benzimidazole?
The yield of pure benzimidazole, m.p. 171-172 °C, is 25 g (85%).
Which derivative is benzimidazole?
Flubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe. Fenbendazole is a benzimidazole that presents a wide spectrum anthelmintic effect.
What are examples of benzimidazole?
Those of interest are mebendazole, flubendazole, fenbendazole, oxfendazole, oxibendazole, albendazole, albendazole sulfoxide, thiabendazole, thiophanate, febantel, netobimin, and triclabendazole.
Which one of the following drugs is a benzimidazole?
Benzimidazole drugs (e.g., anthelmintics albendazole, fenbendazole, oxfenbendazole, thiabendazole, mebendazole; inhibitors of proton pump omeprazole, lansoprasole, pantoprasole) represent substances used in both human and veterinary medicine; however, from the point of view of induction and inhibition of …
What is the pharmacological significance of benzimidazole ring?
The benzimidazole moiety is useful for the development of novel medicinal compounds in pharmaceutical field. Benzimidazole is also a vital pharmacophore, a privileged sub-structure in medicinal chemistry which contributes as a key part for different natural activities [2].
What is the molecular formula for benzimidazole 5 carboxylic acid?
1H-Benzimidazole-5-carboxylic acid PubChem CID 459456 Molecular Formula C8H6N2O2 Synonyms 15788-16-6 1H-Benzimidazole-5-carboxylic Molecular Weight 162.15 Date s Modify 2021-08-07 Create 2005-03-27
What are the basic reactions of benzimidazoles?
Basic reactions given by benzimidazole involves reactions at the 1- and 3-position nitrogens. They readily form salts with acids such as monohydrochloride, monopicrate, mononitrate, monoacetate, and so on [10]. Benzimidazoles, upon alkylation with alkyl halides, yield l-alkylbenzimidazoles and,…
Which is less basic benzene or imidazole?
Benzimidazole is a bicyclic heteroaromatic compound of fused benzene and imidazole. Benzimidazoles are weakly basic in nature, slightly less basic than imidazoles, therefore they are generally soluble in dilute acids.
What is the pK value of benzimidazole?
Benzimidazole is a bicyclic heteroaromatic compound of fused benzene and imidazole. Benzimidazoles are weakly basic in nature, slightly less basic than imidazoles, therefore they are generally soluble in dilute acids. The pK value of benzimidazole was deduced a while ago and found to be pK a1 = 5.30 and pK a2 = 12.3.