What is the meaning for necrosis?
the death of body tissue
Necrosis is the death of body tissue. It occurs when too little blood flows to the tissue. This can be from injury, radiation, or chemicals. Necrosis cannot be reversed. When large areas of tissue die due to a lack of blood supply, the condition is called gangrene.
What is necrosis Definition & Types?
Necrosis (from Ancient Greek νέκρωσις, nékrōsis, “death”) is a form of cell injury which results in the premature death of cells in living tissue by autolysis. Necrosis is caused by factors external to the cell or tissue, such as infection, or trauma which result in the unregulated digestion of cell components.
Why is caseous necrosis called Caseous?
Fusion of macrophages results in the appearance of Langerhans giant cells, in which nuclei are distributed around the periphery of the cytoplasm. As the granulomas age, central necrosis occurs; this is usually referred to as caseous necrosis because of the gross cheesy texture of these zones.
What is Caseous granuloma?
Caseating granuloma means necrosis involving dead cells with no nuclei and debris. Without microscope, the cheese like pattern was seen in the these granulomas .
What causes Caseous necrosis?
Causes. Frequently, caseous necrosis is encountered in the foci of tuberculosis infections. It can also be caused by syphilis and certain fungi. A similar appearance can be associated with histoplasmosis, cryptococcosis, and coccidioidomycosis.
How is Caseous necrosis formed?
Mechanisms of caseous necrosis. tuberculosis-infected macrophages, leading to destruction of surrounding tissue. The host locally destroys its own tissue to control the uninhibited intracellular multiplication of bacilli that would otherwise be fatal (1).
What causes caseous necrosis?
How does caseous necrosis work?
Mechanisms of caseous necrosis. Activated cytolytic T lymphocytes kill M. tuberculosis-infected macrophages, leading to destruction of surrounding tissue. The host locally destroys its own tissue to control the uninhibited intracellular multiplication of bacilli that would otherwise be fatal (1).