Can humans get vesicular stomatitis virus?
Humans can contract vesicular stomatitis by coming into contact with lesions, saliva, or nasal secretions from infected animals. In people, the disease causes an acute influenza- like illness with symptoms such as fever, muscle aches, headache, and malaise.
What type of virus is vesicular stomatitis?
VSV is a zoonotic arbovirus that belongs to the family, Rhabdoviridae, the same family as the rabies viruses. VSV has an 11 kb genome that consists of a single strand of negative-sense RNA.
Is vesicular stomatitis virus a RNA virus?
Vesicular stomatitis virus is a negative-stranded RNA virus. Its nucleoprotein (N) binds the viral genomic RNA and is involved in multiple functions including transcription, replication, and assembly. We have determined a 2.9 angstrom structure of a complex containing 10 molecules of the N protein and 90 bases of RNA.
What does VSV infect?
Vesicular stomatitis is a viral disease which primarily affects horses, cattle, and swine. The agent that causes vesicular stomatitis, VSV, has a wide host range and can occasionally infect sheep and goats.
What cells do VSV infect?
VSV infects a broad range of animals, including cattle, horses, and swine. The genome of the virus codes for five major proteins, glycoprotein (G), matrix protein (M), nucleoprotein (N), large protein (L), and phosphoprotein (P).
Is there a vaccine for vesicular stomatitis?
We have previously developed a fast-acting and efficacious vaccine against Ebola virus (EBOV) using the vesicular stomatitis virus (VSV) platform.
How is VSV transmitted?
Biting flies include horseflies, deer flies, and stable flies. Biological transmission comprises a competent vector becoming infected with vesicular stomatitis virus (VSV) by feeding on blood or feeding on vesicular lesions, amplifying the virus, and transmitting it during subsequent blood-feeding.
What does vesicular stomatitis mean?
: an acute virus disease especially of various domesticated animals (as horses and cows) that resembles foot-and-mouth disease, that is marked by erosive blisters in and about the mouth, and that is caused by any of three single-stranded RNA viruses of the family Rhabdoviridae (genus Vesiculovirus) which sometimes …
What causes vesicular stomatitis?
Vesicular stomatitis is caused by a virus and affects horses, cattle, and pigs. It also rarely affects sheep, goats, and llamas. The virus can be transmitted to humans and may cause flu-like disease. Vesicular stomatitis is seen only sporadically in the US.
What is vesicular stomatitis virus glycoprotein?
Abstract. The glycoproteins (G proteins) of vesicular stomatitis virus (VSV) and related rhabdoviruses (e.g., rabies virus) mediate both cell attachment and membrane fusion. The reversibility of their fusogenic conformational transitions differentiates them from many other low-pH-induced viral fusion proteins.
Can a human get vesicular stomatitis ( vs )?
Vesicular stomatitis (VS) is a viral disease that primarily affects horses and cattle and occasionally swine, sheep, goats, llamas, and alpacas. Humans can also become infected with the disease when handling affected animals, but this is a rare event. Vesicular stomatitis has been confirmed only in the Western Hemisphere.
Is there a cure for vesicular stomatitis?
There is no specific treatment or cure for vesicular stomatitis. Good sanitation and quarantine practices on affected farms usually contain the infection. When definite diagnosis is made on a farm, work with the State Veterinarian’s office to determine necessary quarantine procedures. The following procedures are also recommended:
What to do if your horse has vesicular stomatitis?
Treatment Vesicular stomatitis is treated with supportive care. Since the lesions may be quite painful your veterinarian may prescribe anti-inflammatory drugs. If your horse is having trouble eating, softening their grain in warm water could encourage higher consumption. Softening hay cubes can also help if they are having trouble eating grass/hay.
When was the most recent outbreak of VSV?
The most recent outbreak (VSV-NJ) occurred from 2004 to 2006 resulting in a total of 13 states, 114 counties, 748 premises, and 1,276 affected animals. Mechanisms of pathogenesis and infection. Morbidity rates vary greatly, but can be as high as 90%.