What are warthin finkeldey cells?
Warthin-Finkeldy cells are multinucleated giant cells having an appearance akin to “Grape-like clusters” or “Mulberry.” These are large cells enclosing multiple, round, regular-sized nuclei having inconspicuous nucleoli.
How does the measles virus infect cells?
Wild-type measles virus binds to cells primarily through the cellular receptor SLAM whereas most vaccine strains bind to CD46; however, most measles virus strains can use both CD46 and SLAM as receptors during acute infection (Schneider et al., 2002).
What types of cells does measles infect?
Measles virus infects epithelial cells using nectin-4. Endothelial cells and neurons are also infectable, but the entry receptors are unknown.
What are the virulence factors of measles?
It consists of a helical nucleocapsid, 100-300 nm in diameter, surrounded by an envelope. The envelope is lined by matrix proteins and carries transmembrane hemaglutinin and fusion glycoproteins which are the virulence factors.
What is Paracortical hyperplasia?
Paracortical hyperplasia is the preferential stimulation of the T cell compartment. It is caused by an abnormal expansion of the interfollicular zones but is confined within the lymph node capsule. The population of the compartment is cytologically polymorphous.
How does measles affect the human body?
Measles causes a red, blotchy rash that usually appears first on the face and behind the ears, then spreads downward to the chest and back and finally to the feet. Measles is a childhood infection caused by a virus. Once quite common, measles can now almost always be prevented with a vaccine.
How Does measles virus work?
The virus enters the body through the mouth, nose, or eyes . Once there, it most likely enters the lungs, where it infects immune cells. These cells move to the lymph nodes, where the virus transfers to other cells. These cells travel through the body, releasing virus particles into the blood.
How does measles affect the body?
What is measles made of?
Measles is a very contagious disease caused by a virus. It spreads through the air when an infected person coughs or sneezes. Measles starts with a cough, runny nose, red eyes, and fever. Then a rash of tiny, red spots breaks out.
Is measles RNA or DNA?
The measles virus is a single-stranded RNA virus of the genus Morbillivirus and the family Paramyxoviridae. The virus is related to several viruses that infect animals, including the Canine Distemper Virus.
What causes warthin tumor?
The exact underlying cause of Warthin tumor is currently unknown. However, smoking is thought to increase the risk of developing the tumor. Some studies suggest that radiation exposure and autoimmune disorders may also be associated with Warthin tumor.