What is the Erk gene?
MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development.
Is MAPK a gene?
The MAPK proteins belong to a complex gene family in plants [13]. In plants, MAPKs are involved in cellular responses to the regulation of the cell cycle, plant growth and development, hormones, and responses to biotic and abiotic stresses [7,25].
What is mitogen-Activated Protein kinase 3?
MAPK3 (Mitogen-Activated Protein Kinase 3) is a Protein Coding gene. Diseases associated with MAPK3 include Bile Duct Cancer and Pancreatic Adenocarcinoma. Among its related pathways are PI3K/AKT activation and Cellular response to heat stress. An important paralog of this gene is MAPK1.
Is ERK an active kinase?
MEK phosphorylates and activates a mitogen-activated protein kinase (MAPK). RAF, and ERK (also known as MAPK) are both serine/threonine-selective protein kinases. MEK is a serine/tyrosine/threonine kinase. In the technical sense, RAF, MEK, and MAPK are all mitogen-activated kinases, as is MNK (see below).
What does ERK stand for?
ERK
| Acronym | Definition |
|---|---|
| ERK | Extracellular Signal-Regulated Kinase |
| ERK | Extracellular Receptor Kinase |
| ERK | Everett Raymond Kinstler (painter) |
| ERK | Electronic Records Keeping |
What is the difference between ERK1 and ERK2?
Protein sequences of ERK1 and ERK2 are 84% identical in a given mammal; human ERK1 is larger than human ERK2 due to an extension of 17 amino-acids at its N-terminal and 2 amino-acids at its C-terminal.
Is insulin a mitogen?
Although insulin is a much weaker mitogen [2] than insulin-like growth factors (IGFs), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF), insulin has a very specific mitogenic action that in fact modulates cellular responsiveness to all other growth …
How do I activate ERK?
Both ERK1 and ERK2 (referred to collectively as ERK) are activated by dual phosphorylation on Thr202/185 and Tyr204/187 (human sequences; Thr203/183 and Tyr205/185 rat sequence) mainly by MAPK/ERK Kinases (MEKs) [122]. Upon phosphorylation, ERK can either homodimerize, heterodimerize or remain monomers [66].