Can you live with Kartagener syndrome?
In severe cases, some individuals may require a full lung transplant. In many individuals, the number of respiratory infections begins to decrease by about age 20, and as a result, many people with Kartagener syndrome have near-normal adult lives.
What happens when you have PCD?
Primary ciliary dyskinesia (PCD) is a rare genetic condition that can lead to chronic lung, ear and sinus infections, along with other disorders in children and adults.
Can PCD cause infertility?
Individuals with PCD may experience infertility (inability to conceive naturally) or subfertility (delayed natural conception) due to genetic changes that impact the function of cilia in the Fallopian tubes in women and the sperm tails (flagella*) in men.
Does PCD affect life expectancy?
Prognosis in PCD is good, with a normal life expectancy [12]. Diagnosis of PCD can be problematic, with wide variation in symptoms and scarcity of diagnostic facilities [4]. Age at presentation in one study varied from 4 months to 51 years [13].
Is Kartagener syndrome rare?
Kartagener’s syndrome is a rare genetic disorder. It involves abnormalities of your cilia, which can cause a variety of health problems.
Why would PCD make it difficult to get pregnant or have a baby?
In men, PCD can affect cilia-like structures that help sperm cells move. Because the sperm cells don’t move well, men who have the disease usually are unable to father children. Fertility problems also occur in some women who have PCD. These problems likely are due to faulty cilia in the fallopian tubes.
What are the symptoms of PCD syndrome?
What Are the Symptoms of PCD?
- Chronic wet cough producing sputum, from infancy, that lasts for four weeks or longer.
- Chronic nasal congestion including thick nasal drainage that may lead to sinusitis.
- Recurring pneumonia or chest colds.
- Chronic middle ear infections.
What causes Kartagener’s syndrome?
Kartagener’s syndrome is a rare hereditary disease. It’s caused by a mutation that can occur on many different genes. It’s autosomal recessive, which means you must inherit a mutated gene from both of your parents to develop it.
Is PCD like cystic fibrosis?
PCD is easy to confuse with cystic fibrosis because the two genetic diseases have similar effects on the lungs. In both disorders, mucus accumulates in patients’ lungs, causing frequent infections and severe congestion.
Is it possible to have PCD and Kartagener syndrome?
It’s possible to have only PCD, without situs inversus. If you have both, you have Kartagener’s syndrome. Kartagener’s syndrome is sometimes diagnosed at birth, when a newborn experiences respiratory distress and needs oxygen therapy. But it’s more often discovered in early childhood.
What kind of ciliary dyskinesias does Kartagener syndrome cause?
Kartagener syndrome (KS) is a subset of a larger group of ciliary motility disorders called primary ciliary dyskinesias (PCDs). KS is an inherited autosomal recessive disorder that causes defects in the action of ciliary movement, comprises of triad sinusitis, situs inversus, and bronchiectasis.
What kind of motility disorder is Kartagener syndrome?
Kartagener syndrome (KS) is a subset of a larger group of ciliary motility disorders called primary ciliary dyskinesias (PCDs) [1]. KS is an inherited autosomal recessive disorder that causes defects in the action of ciliary movement, comprises of triad sinusitis, situs inversus, and bronchiectasis [2].
How does Kartagener syndrome affect the respiratory system?
It causes abnormalities in your respiratory tract. They’re known as primary ciliary dyskinesia. It also causes the positioning of some or all of your vital organs to be reversed or mirrored compared to their normal positioning. This is known as situs inversus. There’s no known cure for Kartagener’s syndrome.