What does Hes1 do?
Hes1 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability.
What is KLF4 gene?
KLF4 (Kruppel Like Factor 4) is a Protein Coding gene. Diseases associated with KLF4 include Secretory Meningioma and Cerebral Cavernous Malformations. Among its related pathways are Peptide hormone metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
Is HES1 a transcription factor?
Transcription factor HES1 (hairy and enhancer of split-1) is a protein that is encoded by the Hes1 gene, and is the mammalian homolog of the hairy gene in Drosophila. It is a transcriptional repressor of genes that require a bHLH protein for their transcription.
Where are zinc fingers found?
The canonical members of this class contain a binuclear zinc cluster in which two zinc ions are bound by six cysteine residues. These zinc fingers can be found in several transcription factors including the yeast Gal4 protein.
Where is the SOX2 gene located?
SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells….
| SOX2 | ||
|---|---|---|
| Location (UCSC) | Chr 3: 181.71 – 181.71 Mb | n/a |
| PubMed search | ||
| Wikidata | ||
| View/Edit Human View/Edit Mouse |
Why are zinc fingers important?
Zinc-finger proteins (ZNFs) are involved in several cellular processes acting through different molecular mechanisms. ZNFs have key role in development and differentiation of several tissues. ZNFs are involved in tumorigenesis, cancer progression and metastasis formation.
What is the function of the zinc finger?
Zinc finger proteins are among the most abundant proteins in eukaryotic genomes. Their functions are extraordinarily diverse and include DNA recognition, RNA packaging, transcriptional activation, regulation of apoptosis, protein folding and assembly, and lipid binding.
How does zinc stabilize zinc finger?
A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn2+) in order to stabilize the fold. It often appears as a metal-binding domain in multi-domain proteins.
What is the function of the Hes1 gene?
HES1 is one of the seven members of the Hes gene family (HES1-7). Hes genes code nuclear proteins that suppress transcription. This protein belongs to the basic helix-loop-helix (bHLH) family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription.
How does HES1 affect the differentiation of stem cells?
HES1 influences the maintenance of certain stem cells and progenitor cells. Specifically, HES1 influences the timing of differentiation by repressing bHLH activators, and determines binary cell fate. HES1 has been shown to play a large role in both the nervous, and digestive systems.
Which is Notch ligand does HES1 bind to?
HES1 has been shown to target at least Notch ligands: Dll1, Jagged1 (Jag1), and Neurogenin-2., Dll1, as with other Notch ligands, has been shown to induce neural differentiation, and HES1 binding of Dll1 blocks neural differentiation and leads to the maintenance of the neural stem cells and neural progenitor cells.
Where is HES1 found in a neural stem cell?
HES1 is expressed in both neuroepithelial cells and radial glial cells, both neural stem cells. Hes1 expression, along with that of Hes5, covers the majority of the developing embryo at embryonic day 10.5. After this point, expression of Hes1 is limited to the subventricular zone.