What is adipocyte differentiation?
Adipocyte differentiation is characterized by sequential changes in the expression of specific genes that determine the specific adipocyte phenotype of the cells. This is reflected by the appearance of various early, intermediate and late mRNA/protein markers and triglyceride accumulation.
What is the function of the adipocyte?
The Adipocyte as Functional Endocrine Cell The classical function of the adipocyte is as a calorie storage system accepting chemical energy in the form of glucose and fatty acid from the blood and converting these metabolites to TG for storage during fed conditions via lipogenesis.
Are adipocytes fibroblasts?
Adipose tissues contain multiple types of stromal cells, including fibroblasts, endothelial cells, and immune cells.
What is a Lipoblast?
Lipoblasts are conceptually a precursor or immature form of adipocytes and histologically defined as lipid-containing, mono－ or multivacuolated cells possessing hyperchromatic, indented or often scalloped nuclei.
How is Adipogenesis related to obesity?
However, adipocyte hyperplasia (adipogenesis) is now known to contribute to the increased adipose tissue mass of obesity. Animal studies suggest that hyperplasia occurs in 2 steps: an increase in numbers of preadipocytes and differentiation of preadipocytes into mature (adipokine-secreting) adipocytes.
Why is the adipocyte important?
It is well established that adipocytes (or fat cells) play a vital role in the storage and release of energy throughout the human body. Through the actions of these hormones, adipose tissue plays an important role in the regulation of glucose, cholesterol and the metabolism of sex hormones.
What is difference between adipose and adipocyte?
Adipose tissue is composed of many different cell types, but adipocytes are among the most predominant cells. Adipose tissue stores lipid in the form of triglycerides and cholesterol esters within the lipid droplets that represent specialized organelles inside the adipocyte.
What is the root word of adipocyte?
“pertaining to fat, fatty,” 1743, from Modern Latin adiposus “fatty,” from Latin adipem (nominative adeps, genitive adipis) “soft fat of animals, fat, lard,” which is said to be from Greek aleipha “unguent, fat, anything used for smearing,” a word related to lipos “grease, fat,” from PIE root *leip- “to stick, adhere,” …
What is the suffix of Angioscopy?
scope. Provide the suffix for “angioscopy” scopy. Provide the suffix for “pathology” logy.
What is adipose connective tissue?
adipose tissue, or fatty tissue, connective tissue consisting mainly of fat cells (adipose cells, or adipocytes), specialized to synthesize and contain large globules of fat, within a structural network of fibres. The fat stored in adipose tissue comes from dietary fats or is produced in the body.
What is in adipose tissue?
Adipose tissue (body fat) is crucial for health. Along with fat cells, adipose tissue contains numerous nerve cells and blood vessels, storing and releasing energy to fuel the body and releasing important hormones vital to the body’s needs.
How is the process of adipocyte differentiation described?
Adipocyte differentiation Cellular differentiation is a process in which cells derived mitotically from a common ancestor become different from one another both in their function and in their morphology. Adipocyte differentiation is described by chronological changes in the expression of specific genes that determine the exact adipocyte phenotype.
Which is the dominant feature of adipogenesis?
Adipogenesis is a two-step developmental process in which an undifferentiated mesenchymal cell differentiates into a preadipocyte, which then undergoes a secondary differentiation step to become a lipid-filled adipocyte. As a result of this process, lipid droplets become the dominant feature of the cell.
What are the two classes of adipocyte precursor cells?
Adipocyte precursor cell lines can be segregated into two classes, i.e., pluripotent fibroblasts and unipotent preadipocytes.
How is preadipocyte differentiation used in tissue culture?
Preadipocyte differentiation has therefore been studied primarily by using in vitro models of adipogenesis; much of the knowledge of adipocyte differentiation has been based on the validity of these tissue culture models.