What is the solubility of dexamethasone and Dexamethasone Sodium Phosphate?
The phosphate group makes the molecule more polar, increasing aqueous solubility by more than 500x, from 89 μg/mL for dexamethasone to 50 mg/mL for dexamethasone-phosphate.
Is dexamethasone sodium phosphate water soluble?
Dexamethasone sodium phosphate is a water soluble, inorganic ester of dexamethasone. It is approximately three thousand times more soluble in water at 25°C than hydrocortisone. Chemical Name: 9-fluoro-11β, 17-dihydroxy-16α-methyl-21-[phosphonooxy]pregna-1,4-diene-3, 20-dione disodium salt.
What is the solubility of dexamethasone?
Dexamethasone is practically insoluble in water. It is soluble in ethanol, methanol, acetone, dioxane, and slightly soluble in chloroform. Sigma routinely tests the solubility at 50 mg/mL in ethanol with heat, yielding a clear, colorless to faint yellow solution.
What is the difference between dexamethasone and Dexamethasone Sodium Phosphate?
Dexamethasone is a synthetic corticosteriod and possesses glucocorticoid activity. Dexamethasone sodium phosphate is a salt of dexamethasone that is particularly suitable for intravenous administration because it is highly water soluble, permitting administration of relatively large doses in a small volume of diluent.
How long does im dexamethasone last?
Dexamethasone is a potent steroid with 10 to 20 times the anti-inflammatory properties of prednisolone . It should become maximally effective within 48 hours and the effects should last for 7 to 10 days.
Where to give dexamethasone im?
Dexamethasone may be given by injection if you can’t take it by mouth. It can also be given by injection directly into a joint, or the soft tissue around a joint, to reduce inflammation, for example in rheumatoid arthritis, tennis elbow, golfer’s elbow or bursitis.
Can you give dexamethasone im?
Dexamethasone may be given via intravenous (IV) or intramuscular (IM) administration when used to treat potentially serious conditions, such as cerebral edema (swelling of the brain) or shock. The usual IV or IM dose of this drug is 0.4 mg to 10 mg, but may be significantly higher in some cases.
What is Dex injection?
Dexa Injection belongs to the class anticonvulsant. It works by reducing the excitation of the brain cells by inhibiting the sodium channels thus inhibits the repetitive firing of brain cells. Whenever you take more than one medicine, or mix it with certain foods or beverages, you”re at risk of a drug interaction.