Who manufactures Oncaspar?
Baxter International has entered an agreement with Sigma-Tau Finanziaria to acquire its Oncaspar (pegaspargase) product portfolio for around $900m. Oncaspar is a first-line biologic used as part of a multi-agent chemotherapy regimen to treat acute lymphoblastic leukemia (ALL).
Who makes asparaginase?
Asparaginase produced by Dickeya dadantii (formerly called Erwinia chrysanthemi) instead is known as crisantaspase (BAN), and is available in the United Kingdom under the brand name Erwinase. One of the E.
Is asparaginase available in the US?
Currently, 3 asparaginase formulations are available in the United States, Escherichia coli native asparaginase (ASNase), Pegaspargase, and Erwinase.
What is Pegaspargase made of?
Pegaspargase (Oncaspar®), a pegylated form of native Escherichia coli-derived l-asparaginase (hereafter referred as E. colil-asparaginase), is indicated in the USA and EU for the treatment of acute lymphoblastic leukaemia (ALL) as a component of multi-agent chemotherapy in paediatric and adult patients.
How is Pegaspargase administered?
Pegaspargase is given as an injection into a large muscle (intramuscular or IM). Depending on your dose, the medication may need to be divided into two injections. Pegaspargase may be given into the vein as an infusion (intravenous or IV). There is no pill form of pegaspargase.
How much does Pegaspargase cost?
The cost for Oncaspar injectable solution (750 intl units/mL) is around $21,245 for a supply of 5 milliliters, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
How is asparaginase made?
There are 3 types of asparaginase: asparaginase made from a type of bacteria called Escherichia coli (also known by its brand Spectrila) asparaginase made from the Erwinia chrysanthemia bacteria (Erwinase) long acting (pegylated) asparaginase (also known as pegaspargase)
Is asparaginase in asparagus?
“Asparagine is frequently found in various animal sources including beef, poultry, eggs, fish and seafood. It is also found in many vegetables including asparagus, potatoes, nuts, legumes and soy.
How much does asparaginase cost?
The mean total drug costs for Erwinia asparaginase were $126,831, which corresponds with 149 vials of Erwinia asparaginase. The costs of the drug asparaginase itself accounted for 44.1%, 74.5%, and 19.2% of the total treatment costs of the intensification phase for the three groups, respectively.
Is there a generic for oncaspar?
GENERIC NAME: PEGASPARGASE – INJECTION (peg-ASP-are-gace)
Is there a generic for Oncaspar?
What kind of cancer is Oncaspar used for?
This medicine is authorised for use in the European Union. Oncaspar is a cancer medicine used in adults and children to treat acute lymphoblastic leukaemia (ALL), a cancer of white blood cells called lymphoblasts. Oncaspar is used in combination with other cancer medicines.
Where can I get a prescription for Oncaspar?
Oncaspar can only be obtained with a prescription and only healthcare professionals with experience of cancer treatments should prescribe and give the medicine. The healthcare professional should give the medicine in a hospital where resuscitation equipment is available.
How much Pegaspargase is in a vial of Oncaspar?
Oncaspar (pegaspargase) injection is supplied as a clear, colorless, preservative-free, isotonic sterile solution in phosphate-buffered saline, pH 7.3, for intramuscular use or for dilution prior to intravenous infusion. Each vial of Oncaspar contains 3,750 International Units of pegaspargase in 5 mL of solution.
When did Oncaspar get a marketing authorisation in the EU?
As for all medicines, data on the use of Oncaspar are continuously monitored. Side effects reported with Oncaspar are carefully evaluated and any necessary action taken to protect patients. Oncaspar received a marketing authorisation valid throughout the EU on 14 January 2016. Please note that the size of the above document can exceed 50 pages.