What is the Ukpds study?
The UK Prospective Diabetes Study (UKPDS) was a landmark randomised, multicentre trial of glycaemic therapies in 5,102 patients with newly diagnosed type 2 diabetes.
What is Vadt trial?
The primary goal of the Veterans Affairs Diabetes Trial (VADT) was to compare the effects of intensive and standard glucose control on cardiovascular events.
What is Advance trial?
ADVANCE (Action in Diabetes and Vascular Disease-PreterAx and DiamicroN Controlled Evaluation) is an ongoing large-scale prospective randomised clinical trial aimed at investigating the effects of blood pressure lowering and intensive blood glucose control in high risk diabetic patients on major macrovascular and …
What are the symptoms of advanced diabetes?
A high blood sugar level can lead to diabetes symptoms such as: increased thirst. frequent urination. increased hunger….Early symptoms
- increased thirst.
- increased hunger.
- fatigue.
- blurry vision.
- frequent urination that interrupts your sleep.
- irritability.
- mood changes.
- unexpected weight loss.
What is the finding of the Accord study?
The ACCORD lipid trial involved 5,518 participants. Researchers found that, overall, the combination therapy was safe, but it did not lower the risk of heart attack, stroke, or death from cardiovascular disease more than statins alone.
When did the United Kingdom Prospective Diabetes Study ( UKPDS ) begin?
Lancet 1998; 352:837–853. The United Kingdom Prospective Diabetes Study (UKPDS) was a prospective, multi-centre cohort study, held across 23 hospitals in the UK over 20 years, examining the rates of micro- and macrovascular complications in patients who, in 1976, had recently been diagnosed with Type 2 Diabetes Mellitus.
How does glucose level affect risk of retinopathy?
Effect of initial glucose levels: Patients with higher glucose levels (measured by HbA1c) at the beginning of the trial were more likely to have retinopathy. Every 1% decrement in HbA1c level led to a 31% lower risk of retinopathy and a 19% reduced risk of cataract extraction.
What was the design of The UKPDS study?
The design of the UKPDS was explicit and was directed by prespecified protocols with appropriate randomization of patients. Laboratory and clinical tests were performed by accepted methodologies, and all end points were satisfactorily documented.
What are the results of the Stockholm Diabetes Study?
Some of these studies have also demonstrated that treatment that lowers blood glucose reduces the risks of diabetic retinopathy, nephropathy, and neuropathy. Notable are the results of the Diabetes Control and Complications Trial (DCCT) ( 2) and the similarly designed but smaller Stockholm Diabetes Intervention Study ( 3 ).