What is the difference between diabetes insipidus and SIADH?
Impaired AVP secretion or response results in impaired renal concentration and is termed diabetes insipidus (DI). Hyponatremia that results from AVP production in the absence of an osmotic or hemodynamic stimulus is termed syndrome of inappropriate antidiuretic hormone secretion (SIADH).
Can diabetes insipidus cause hyponatremia?
Conclusions: Hyponatremia is not commonly seen in patients with diabetes insipidus. However, it can occur if a patient presents with profound gastrointestinal losses or in adrenal crisis. Suspicion for diabetes insipidus should be raised when sodium level remains high despite free water replacement.
Does cerebral salt wasting exist?
Cerebral salt wasting (CSW) is another potential cause of hyponatremia in those with CNS disease, particularly patients with subarachnoid hemorrhage. CSW is characterized by hyponatremia and extracellular fluid depletion due to inappropriate sodium wasting in the urine [5].
Why is serum sodium high in diabetes insipidus?
Diabetes insipidus is present when the serum osmolality is raised (>295 milliOsmol/kg) with inappropriately dilute urine (urine osmolality <700 milliOsmol/kg). The serum sodium is often elevated due to excess free water losses.
What is the difference between ADH and SIADH?
SIADH causes the body to retain too much water. ADH is a substance produced naturally in an area of the brain called the hypothalamus. It is then released by the pituitary gland at the base of the brain.
How do you manage cerebral salt wasting?
Management of cerebral salt-wasting syndrome centers on correction of intravascular volume depletion and hyponatremia, as well as on replacement of ongoing urinary sodium loss, usually with intravenous (IV) hypertonic saline solutions.
Is sodium high or low in diabetes insipidus?
What electrolyte imbalance is associated with diabetes insipidus?
Electrolyte imbalance Diabetes insipidus can cause an imbalance in minerals in your blood, such as sodium and potassium (electrolytes), that maintain the fluid balance in your body.