What is icilin?
Icilin (AG-3-5) is a synthetic super-agonist of the transient receptor potential M8 (TRPM8) ion channel. Although structurally not related with menthol, it produces an extreme sensation of cold, both in humans and animals. It is almost 200 times more potent than menthol, and 2.5 times more efficacious.
What is the TRPM8 channel?
TRPM8 is an ion channel: upon activation, it allows the entry of Na+ and Ca2+ ions to the cell, which leads to depolarization and the generation of an action potential. The signal is conducted from primary afferents (type C- and A-delta) eventually leading to the sensation of cold and cold pain.
What does TRPM8 stand for?
GeneCards Summary for TRPM8 Gene TRPM8 (Transient Receptor Potential Cation Channel Subfamily M Member 8) is a Protein Coding gene.
Is TRPM8 a Nociceptor?
TRPM8 encodes a nociceptor expressed in dural afferent fibres involved in meningeal nociception, providing the first direct genetic link between migraine and the trigeminal vascular system.
What is piezo and Piezo2?
Piezo1 and related Piezo2 (Fam38B) are vertebrate multipass transmembrane proteins with homologs in invertebrates, plants, and protozoa. Overexpression of mouse Piezo1 or Piezo2 induced two kinetically distinct MA currents.
What is piezo protein?
What are Piezo proteins? Piezo proteins constitute a family of excitatory ion channels directly gated by mechanical forces. These ion channels are involved in cell mechanotransduction — the conversion of mechanical forces into biological signals.
What is Piezol?
Piezo is derived from the Greek πιέζω, which means to squeeze or press, and may refer to: PIEZO1, a mechanosensitive ion protein. Piezoelectricity, electrical charge built up in response to mechanical stress. Piezometer, a device that measures the pressure of groundwater at a certain point.
What are piezo receptors?
Piezo channels are recently discovered sensors that serve to detect and transduce mechanical force into physiological effect via transmembrane ion flux.
How do piezo proteins work?
Piezo proteins function as sensors in the body for mechanical stimuli such as touch, bladder fullness, and blood pressure, with the latest results shedding new light on the roles of these proteins in human diseases and potential new therapeutic strategies.