Do dendritic cells secrete IL-10?
Different APC, including dendritic cells (DC), monocytes, macrophages and B-cells, as well as effector and regulatory T lymphocytes, produce IL- 10 [14].
Where is interleukin 10 produced?
In humans, IL-10 is encoded by the IL10 gene, which is located on chromosome 1 and comprises 5 exons, and is primarily produced by monocytes and, to a lesser extent, lymphocytes, namely type-II T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and in a certain subset of activated T cells and B cells …
What cytokines are produced by dendritic cells?
Through the cytokines they secrete, e.g.: IL-12, IL-23 or IL-10 as well as the surface molecules they express, e.g.: OX40-L [33] or ICOS-l [34] DCs can polarize naïve T cells into Th1, Th2, Treg or Th17.
Do dendritic cells produce IL 15?
IL-15, secreted by IL-15 dendritic cells (DCs), provides an important signal for DC-mediated γδ T cell proliferation and IFN-γ production.
What is the function of IL-10?
Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that plays a central role in limiting host immune response to pathogens, thereby preventing damage to the host and maintaining normal tissue homeostasis.
Do macrophages produce IL-10?
IL-10 is produced by macrophages in diverse immune settings and is critical in limiting immune-mediated pathology. In helminth infections, macrophages are an important source of IL-10; however, the molecular mechanism underpinning production of IL-10 by these cells is poorly characterized.
Is IL-10 antiinflammatory or anti-inflammatory?
Although typically classified as anti-inflammatory and immunosuppressive cytokine, the effects of IL-10 are highly context-dependent and there are several scenarios where IL-10 enhances immune cell activation and proliferation causing the release of pro-inflammatory cytokines.
What do dendritic cells produce?
Dendritic cells also contribute to the function of B cells and help maintain their immune memory. Dendritic producing cytokines and other factors that promote B cell activation and differentiation.
Do dendritic cells produce TNF?
Dendritic cell-derived TNF-alpha is responsible for development of IL-10-producing CD4+ T cells. Cell Immunol. 2010;261(1):37-41.
Is IL-10 a proinflammatory cytokine?
IL-10 is considered a potent antiinflammatory cytokine that strongly inhibits the production of proinflammatory cytokines.
How do dendritic cells grow?
Our dendritic cells are immature, but you can easily activate or mature them by adding lipopolysaccharides (LPS), poly(I:C), or other pathogen pattern molecules. Alternatively, you could use cytokines, such as IFNγ or TNFα, in combination with prostaglandin to achieve a similar result.