Can you take prednisone with Gleevec?
You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects.
Is imatinib an immunosuppressant?
The drug does so by stimulating the bone marrow to make more neutrophils and macrophages, immune cells that are important for resisting bacterial infection. “This was surprising because there are reports that imatinib can be immunosuppressive in some patients,” Kalman says.
What is the mechanism of action for imatinib?
Imatinib works by binding close to the ATP binding site of bcr-abl, locking it in a closed or self-inhibited conformation, and therefore inhibiting the enzyme activity of the protein semi-competitively.
What is the indication of imatinib?
Currently, FDA approved indications include: First-line adult and pediatric Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase (Ph+ CML CP): IRIS Trial: treatment with imatinib in adults with newly diagnosed CML resulted in a 10-year overall survival rate of 83.3%.
How long does imatinib stay in your system?
Imatinib has a half-life of around 18 hours. A drug’s half-life is the time it takes for your body to clear half of a dose of the drug.
Is imatinib a cure?
Imatinib mesylate has transformed the treatment for chronic myeloid leukemia (CML). The vast majority of patients obtain hematologic remission, with a low probability of progression of disease. Yet imatinib rarely cures CML, and current recommendations dictate lifelong treatment with imatinib.
What happens if I stop taking imatinib?
Update on Stopping Imatinib in CML A total of 61% of patients lost undetectable minimal residual disease at a median of 2.5 months after discontinuation of imatinib for CML; no recurrences occurred after 22 months.
How long can you take imatinib?
Optimal duration of therapy is unknown but generally imatinib should be continued for 6–9 months, after which additional tumor shrinkage is usually minor.
Can I take vitamin D with imatinib?
Based on interaction studies of imatinib with the cytochrome P450 (CYP450) inhibitors VID400 and ketoconazole, it is proposed that imatinib may interfere with the vitamin D3 cascade due to its metabolism by CYP27B1, which is involved in vitamin D3 metabolism.
When is the best time to take imatinib?
Taking imatinib tablets or capsules You should take it with a meal. The tablets or capsules must be swallowed whole with a glass of water. They should not be chewed, opened or crushed. Take them at the same time every day.