What is Pregenomic RNA?
Pregenomic RNA (pgRNA) is a direct transcription product of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA), and it plays important roles in viral genome amplification and replication.
What is Pregenomic?
Pregenomic RNA (pgRNA) is an emerging serological marker for chronic hepatitis B virus (HBV) infection. While pgRNA is principally the template for viral proteins and viral DNAs, additional novel functions for the serum pgRNA have recently been described.
Where are Hepadnavirus genomes produced?
The major site of hepadnavirus infection is the hepatocyte. Hepadnaviruses contain a relaxed circular double-stranded DNA genome which is converted in the nucleus to covalently closed circular DNA (cccDNA), which is used as the virus transcriptional template to produce ‘pregenomic’ RNA and virus mRNA.
Is there a vaccine for Hepadnavirus?
Two different vaccines based on hepadnaviral core particles have now been tested in clinical trials and were found to be safe, and improved dosing will likely provide more robust demonstration of effectiveness in humans.
What is SARS rna2?
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious RNA coronavirus responsible for the pandemic of the coronavirus disease 2019 (COVID-19).
Do all RNA viruses use reverse transcriptase?
A reverse transcriptase (RT) is an enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription….Reverse transcriptase.
| Reverse transcriptase (RNA-dependent DNA polymerase) | |
|---|---|
| CDD | cd00304 |
| showAvailable protein structures: |
Can RNA be circular?
Circular RNA (or circRNA) is a type of single-stranded RNA which, unlike linear RNA, forms a covalently closed continuous loop. In circular RNA, the 3′ and 5′ ends normally present in an RNA molecule have been joined together. Many types of circular RNA arise from otherwise protein-coding genes.