Can GVHD occur in autologous transplant?
Graft versus host disease (GVHD) is a common and serious complication of allogeneic stem cell transplantation. However, it is rarely seen in recipients of autologous cells, and would likely have a very different etiology as no alloantigens are introduced to the hosts.
What is the mortality rate of autologous stem cell transplant?
Results: Forty-two patients (2.8%) died from treatment-related reasons <100 d from ASCT. The median time to death was 38 d from ASCT (0-99). The risk of TRM varied according to the diagnoses. The highest risk was observed in patients with AL amyloidosis (24%) followed by NHL (4.4%) and MM (1.9%).
What are the therapeutic advantages of an autologous stem cell transplant?
Faster recovery of cell counts, lesser transplant morbidity, shorter hospital stay and reduced cost compared with marrow autografts have been the main advantages of autologous peripheral blood cell over marrow transplants.
Can you get graft vs host disease from an autologous stem cell transplant?
Despite occurring in up to 50% of patients undergoing allogeneic HSCT, the incidence of graft-versus-host disease (GVHD) after autologous HSCT is reportedly only 5-20%.
Can GVHD cause fatigue?
Patients with severe GVHD after allogeneic SCT (i.e. grades III and IV, acute GVHD or extensive chronic GVHD) may experience many acute and chronic medical problems, are treated with several drugs and other therapies, which may influence an unstable clinical balance and may provoke fatigue.
Is autologous stem cell transplant better than allogeneic?
Autologous transplants have a lower risk of life-threatening complications; there is no risk of GVHD and no need for immunosuppressive therapy to prevent GVHD and graft rejection. Immune reconstitution is more rapid than after an allogeneic transplant and there is a lower risk of opportunistic infections.
Is GVHD an autoimmune disease?
Many of the clinical, histological and serological manifestations of chronic graft-versus-host disease (GVHD) resemble autoimmune disease (AD), and although the differences are significant, they may be more semantic than biological.