What are the steps to make a tablet?
The manufacturing of tablet involves numerous unit processes, including:
- Particle size reduction and sizing.
- Blending.
- Granulation.
- Drying.
- Compaction.
- Testing of physical properties.
- Coating.
What is tablet process?
• Tablets formation process consist of a series of steps. (unit processes)– weighing, milling, mixing, granulation, drying, compaction, (frequently) coating and packaging. Regardless of the method used the unit processes – weighing, milling and mixing, are the same; subsequent steps differ.
Which excipients are used in tablet Mfg?
Table 1 Common excipients used in tablets
| Excipient | Examples |
|---|---|
| Disintegrants | Compounds which swell or dissolve in water e.g. starch, cellulose derivatives and alginates, crospovidone |
| Glidants | Colloidal anhydrous silicon and other silica compounds |
| Lubricants | Stearic acid and its salts (e.g. magnesium stearate) |
Why friability test is done?
Friability testing is a laboratory technique used by the pharmaceutical industry to test the durability of tablets during transit. The result is inspected for broken tablets, and the percentage of tablet mass lost through chipping.
What is milling in tablet manufacturing?
Milling involves the application of mechanical energy to physically break down coarse particles to finer ones and is regarded as a “top–down” approach in the production of fine particles. Fine drug particulates are especially desired in formulations designed for parenteral, respiratory and transdermal use.
What is friability formula?
The formula for friability test use in tablets: w2= Final weight of tablets or weight after the test.
What is friability unit?
Friability is defined as the % of weight loss by tablets due to mechanical action during the test. Rotate the drum 100 times with a speed of 25 rpm. For tablets with a unit mass equal to or less than 650 mg, take a sample of whole tablets corresponding to 6.5 g.