What is the difference between clonal selection and clonal expansion?
Clonal selection is the theory that specific antigen receptors exist on lymphocytes before they are presented with an antigen due to random mutations during initial maturation and proliferation. After antigen presentation, selected lymphocytes undergo clonal expansion because they have the needed antigen receptor.
What is clonal selection theory quizlet?
Clonal selection. fundamental feature of the immune system based on the fact that every individual possesses numerous clonally derived lymphocytes, each clone has arisen from a single precursor and is capable of recognizing and responding to a distinct antigenic determinant.
What is clonal expansion quizlet?
Clonal expansion is the: production of daughter cells all arising originally from a single cell. In a clonal expansion of lymphocytes, all progeny share the same antigen specificity.
What is the clonal expansion?
Definition. The proliferation of B-lymphocytes and T-lymphocytes activated by clonal selection in order to produce a clone of identical cells. This enables the body to have sufficient numbers of antigen-specific lymphocytes to mount an effective immune response.
What is an example of clonal selection?
Clonal selection theory of lymphocytes: 1) A hematopoietic stem cell undergoes differentiation and genetic rearrangement to produce 2) immature lymphocytes with many different antigen receptors. Those that bind to 3) antigens from the body’s own tissues are destroyed, while the rest mature into 4) inactive lymphocytes.
What do you mean by clonal selection?
Definition. Clonal selection is a process proposed to explain how a single B or T cell that recognizes an antigen that enters the body is selected from the pre-existing cell pool of differing antigen specificities and then reproduced to generate a clonal cell population that eliminates the antigen.
What is clonal expansion of B cells?
Clonal expansion is the process by which daughter cells arise from a parent cell. During B cell clonal expansion, many copies of that B cell are produced that share affinity with and specificity of the same antigen.
What does clonal selection mean?
Clonal selection is a process proposed to explain how a single B or T cell that recognizes an antigen that enters the body is selected from the pre-existing cell pool of differing antigen specificities and then reproduced to generate a clonal cell population that eliminates the antigen.
What is clonal deletion quizlet?
Clonal deletion. B cells and T cells that react to self Ag are destroyed in the primary lymphatic organs. The cells that are not eliminated by clonal deletion are available in your library/repertoire for clonal selection.
Which of the following is produced by cytotoxic T cell?
Cytotoxic T cells produce cytotoxins which cause apoptosis of infected cells. Self proteins of infected cells are not recognized by cytotoxic T cells.
What is the example of clonal selection?
What is meant by clonal selection?