What is micronization process?
Micronization is the process of reducing the average diameter of a solid material’s particles. The term micronization usually refers to the reduction of average particle diameters to the micrometer range, but can also describe further reduction to the nanometer scale.
What is meant by micronized?
When a drug is said to be micronized, that means its particle size is generally less than 50 microns. When an API is micronized, its particle size is about 4 to 10 times smaller than conventional drug particles.
What are nano suspensions?
Nanosuspension consists of the pure poorly water-soluble drug without any matrix material suspended in dispersion. Preparation of nanosuspension is simple and applicable to all drugs which are water insoluble.
What is the importance of micromeritics in the manufacture of tablets and capsules?
Micromeritic properties of a particle, i.e. the particle size in a formulation, influence the physical stability of the suspensions and emulsions. The smaller the size of the particle, the better the physical stability of the dosage form owing to the Brownian motion of the particles in the dispersion.
What is micronization API?
Micronization is a process for reducing the diameter of a solid material’s particles to enable the solubility of Active Pharmaceutical Ingredients (APIs). Whether administered orally or topically, this solubility is a key factor in bioavailability, and ultimately, the effectiveness of a drug.
What is the difference between milling and micronization?
Using physical components to reduce the size of a given compound is called milling. Micronization means micronizing or reducing the size, whereas milling means crushing the particles for reducing their diameter. One can reduce the size of the particle by using milling in the range of micrometer and nanometer.
How do you make a Nanosuspension?
Preparation of nanosuspension is simple and applicable to all drugs which are water insoluble. Nanosuspensions are prepared by using wet mill, high pressure homogenizer, emulsion solvent evaporation, melt emulsification and supercritical fluid techniques.
How big is a nanocrystal?
Nanocrystals are aggregates of atoms that combine into a “cluster” and are less than 1 μm in size. Typical sizes range between 10 and 400 nm. Their physical and chemical properties are observed somewhere between that of bulk solids and molecules.
Why do we need to study Micromeritics?
The Science and Technology of small particles is known as Micromeritics. Knowledge and control of the size and the size range of particle is of profound importance in pharmacy. Size and surface area can be related to the physical, chemical and pharmacological properties of a drug.
What is the importance of Micromeritics?
5. Micromeritics • Micromeritics is the science and technology of small particles. Knowledge and control of the size and the size range of particles are of significant importance in pharmacy because the size and surface area of a particle related to the physical, chemical and pharmacologic properties of a drug.
How does a jet mill work?
A jet mill grinds materials by using a high speed jet of compressed air or inert gas to impact particles into each other. Jet mills can be designed to output particles below a certain size while continuing to mill particles above that size, resulting in a narrow size distribution of the resulting product.
What are nanocapsules made of?
A nanocapsule is a nanoscale shell made from a nontoxic polymer. They are vesicular systems made of a polymeric membrane which encapsulates an inner liquid core at the nanoscale.
How does micronization technology help the food industry?
Micronization technology for the food industry. Advanced technology enabling the production of fine particles of various structures down to approximately 1µm. Micron-sized powders of fat and other ductile edibles offer opportunities for new products and inventive processing in the food industry.
How is technology being used in the classroom?
The strategy of blending online learning with school-based instruction is often utilized to accommodate students’ diverse learning styles and to enable them to work before or after school in ways that are not possible with full-time conventional classroom instruction.
How are digital resources used in the classroom?
Use digital resources well: Schools can use digital resources in a variety of ways to support teaching and learning. Electronic grade books, digital portfolios, learning games, and real-time feedback on teacher and student performance, are a few ways that technology can be utilized to power learning.
How is technology being used to power learning?
Electronic grade books, digital portfolios, learning games, and real-time feedback on teacher and student performance, are a few ways that technology can be utilized to power learning. High Tech High – High Tech High (HTH) is a network of eleven California charter schools offering project-based learning opportunities to students in grades K-12.