What is a RPR serology test?
RPR (rapid plasma reagin) is a screening test for syphilis. It measures substances (proteins) called antibodies that are present in the blood of people who may have the disease.
What does it mean when RPR is positive?
A positive test result may mean that you have syphilis. If the screening test is positive, the next step is to confirm the diagnosis with a more specific test for syphilis, such as FTA-ABS . The FTA-ABS test will help distinguish between syphilis and other infections or conditions.
What is syphilis serology RPR?
A rapid plasma reagin (RPR) test is a blood test used to screen you for syphilis. It works by detecting the nonspecific antibodies that your body produces while fighting the infection. Syphilis is a sexually transmitted infection (STI) caused by the spirochete bacterium Treponema pallidum.
What is RPR test principle?
The principle of the RPR test is a flocculation reaction between the RPR antigen and the reagin. The reaction can be seen macroscopically on the test slide as clumping of the carbon particles. STORAGE Store reagents refrigerated at 2″ – 8oC.
Does RPR stay positive after treatment?
Following successful treatment, the RPR declines over time and may become nonreactive. However, the RPR may remain reactive at a low titer (generally <1:8), a condition referred to as the serofast state. The serofast state does not apply to this patient because he has no previous syphilis history.
Is RPR a serology test?
Normal: Non-Reactive; See Important Comments. The Rapid Plasma Reagin (RPR) test is a nontreponemal test detecting antibodies (reagin) reacting with the cardiolipin-lecithin-cholesterol antigen.
How is Treponema pallidum diagnosis?
Direct diagnostic methods include the detection of T pallidum by microscopic examination of fluid or smears from lesions, histological examination of tissues or nucleic acid amplification methods such as polymerase chain reaction (PCR). Indirect diagnosis is based on serological tests for the detection of antibodies.
How is Treponema pallidum diagnosed?
What is the difference between RPR and Treponema pallidum?
Syphilis tests are available in two categories: treponemal tests (antibody tests to the organism itself, Treponema pallidum) and non-treponemal tests (such as RPR, which detects non-treponemal reagin antibodies; commonly seen with syphilis, but present in many other disease and non-disease states).