Is innohep safe during pregnancy?
During pregnancy, Innohep should be used only when prescribed. If you become pregnant or think you may be pregnant, tell your doctor immediately. Since the benzyl alcohol in Innohep can affect a fetus a preservative-free product should be used in pregnant women if possible.
Is Tinzaparin contraindicated in pregnancy?
The administration of medications containing benzyl alcohol as a preservative to premature neonates has been associated with a fatal “Gasping Syndrome.” Because benzyl alcohol may cross the placenta, INNOHEP® (tinzaparin) preserved with benzyl alcohol should be used with caution in pregnant women only if clearly needed …
What are the contraindications of enoxaparin?
Contraindications
- Known hypersensitivity to enoxaparin (urticaria, anaphylactic reactions) or any heparin products.
- Active major bleeding such as gastrointestinal bleed.
- History of heparin-induced thrombocytopenia within the past 100 days.
- Active gastric or duodenal ulcers.
- Hemorrhagic cerebrovascular accident.
How long does enoxaparin stay in your system?
Elimination: A single dose of a subcutaneous injection of enoxaparin has an elimination half-life of 4.5 hours.
Can innohep cause miscarriage?
There have been four reports of fetal death/miscarriage in pregnant women who received tinzaparin. This also included pregnant women with a history of spontaneous abortion and/or high risk. Six percent of pregnancies were complicated by fetal distress.
Can heparin harm a fetus?
Is Low Molecular Weight Heparin safe for my unborn baby? For pregnant women and women who have given birth, heparin is the anticoagulant of choice and is recommended by the Royal College of Obstetricians and Gynaecologists. It does not cross the placenta, and therefore is considered to be safe.
Does innohep affect INR?
Adult Dosage As INNOHEP® may theoretically affect the PT/INR, patients receiving both INNOHEP® and warfarin should have blood for PT/INR determination drawn just prior to the next scheduled dose of INNOHEP®.
Can tinzaparin cause miscarriage?
When should I take enoxaparin during pregnancy?
Patients will receive a fixed dose of 40 mg of enoxaparin subcutaneous daily. Treatment will start once positive pregnancy test and will be continued until abortion or delivery (if premature), or 37 weeks of pregnancy.
Who should not use enoxaparin?
You should not use enoxaparin if you are allergic to enoxaparin, heparin, benzyl alcohol, or pork products, or if you have: active or uncontrolled bleeding; or. if you had decreased platelets in your blood after testing positive for a certain antibody while using enoxaparin within the past 100 days.
When should I stop taking enoxaparin during pregnancy?
Women should be advised to stop their LMWH when contractions begin. For a planned delivery, most guidelines recommend stopping enoxaparin within 24 hours, and this is especially important if an epidural is desired.
Can enoxaparin be given in the arm?
Enoxaparin is given by a subcutaneous injection. A subcutaneous injection is an injection into the tissue just below the skin, similar to an insulin injection. The injections can be given in the legs, arms or abdomen.
Is it safe to take Innohep during pregnancy?
In addition, medications that have been shown to be safe for use in pregnancy in humans but have caused problems in laboratory animals are also given a pregnancy Category B rating. Innohep is thought to be safe for use during pregnancy for several reasons. In animal studies, the drug did not increase the risk of birth defects.
Can you use Innohep in an intravenous setting?
INNOHEP® is not intended for intramuscular or intravenous administration. INNOHEP® cannot be used interchangeably (unit for unit) with heparin or other low molecular weight heparins as they differ in manufacturing process, molecular weight distribution, anti-Xa and anti-IIa activities, units, and dosage.
Can a person have an allergic reaction to Innohep?
An allergic reaction to sulfites occurs more frequently in asthma patients than in people that do not have asthma. If you have ever had an allergic reaction to sulfites, ask your pharmacist if your product has sulfites in it. Innohep may reduce the number of clot-forming cells (platelets) in your blood.