What is the difference between GLUT1 and GLUT4?
GLUT1 is expressed in most cells, is localized primarily at the cell membrane, and is thought to participate mainly in basal glucose transport in muscle. GLUT4 is expressed only by cells that accelerate glucose transport in response to insulin (skeletal muscle, heart muscle, and adipose cells).
What is the function of GLUT3?
GLUT3 facilitates the transport of glucose across the plasma membranes of mammalian cells. GLUT3 is most known for its specific expression in neurons and has originally been designated as the neuronal GLUT.
What is the function of GLUT1?
The glucose transporter GLUT1, a plasma membrane protein that mediates glucose homeostasis in mammalian cells, is responsible for constitutive uptake of glucose into many tissues and organs. Many studies have focused on its vital physiological functions and close relationship with diseases.
Is GLUT2 bidirectional?
The hepatic glucose transporter, GLUT2, facilitates bidirectional glucose transport across the hepatocyte plasma membrane under insulin regulation.
Where is GLUT5 found?
GLUT5 (SLC2A5) is a high-affinity fructose transporter primarily expressed at the apical surface of intestinal epithelial cells but also at lower levels in testis, kidney, brain, skeletal muscle and white adipose tissue (WAT)15.
How does GLUT3 work?
GLUT3 has a low Km for glucose of 1.6 mM. It transports glucose into brain cells at a rate that is independent of the plasma level of glucose when it exceeds the physiological range of 4–10 mM. GLUT4 functions for the insulin-dependent translocation of glucose.
Where is GLUT3 found?
GLUT3 is the most prominent glucose transporter isoform expressed in adult brain, where it tends to be preferentially located in neurones, rather than in other cell types, such as glia or endothelial cells. It is also widely distributed in other human tissues, having been detected in the liver, kidney and placenta.
What is glut biochemistry?
Glucose transporter (GLUT) is a facilitative transport protein involved in glucose translocation across the cell membrane.
Where is GLUT2 found?
liver
GLUT2 is a facilitative glucose transporter located in the plasma membrane of the liver, pancreatic, intestinal, kidney cells as well as in the portal and the hypothalamus areas.
What are GLUT receptors?
Glucose transporter (GLUT) is a facilitative transport protein involved in glucose translocation across the cell membrane. From: Ocular Transporters and Receptors, 2013.
Is GLUT5 insulin independent?
Fructose can enter cells via the insulin-independent GLUT5 fructose transporter. In hepatocytes, fructose is phosphorylated to fructose-1-phosphate (F1P) by the enzyme fructokinase.