What does high IgG in CSF mean?
A CSF IgG index measures the levels of IgG in your cerebrospinal fluid. High levels of IgG can mean you have an autoimmune disorder. An autoimmune disorder causes your immune system to attack healthy cells, tissues, and/or organs by mistake. These disorders can cause serious health problems.
What is a normal IgG synthesis rate?
The reference interval is –9.9 to +3.3 mg per day. Negative values are considered normal. Multiple sclerosis patients usually have a synthesis rate >8.0….Multiple Sclerosis Panel.
| Test | Reference Range |
|---|---|
| IgG index | 0.0 – 0.7 mg/dL |
| Oligoclonal bands | Absent |
What is CNS IgG synthesis?
IgG synthesis within the central nervous system is the expression of a local pathologic immune reaction. Its detection is of great importance in a large number of neurologic diseases, especially multiple sclerosis (MS).
What is normal IgG in CSF?
reference range: CSF Albumin: 5-34 mg/dL; CSF IgG: 0-4.5 mg/dL; Serum Albumin (Adult): 3.5 – 4.9 g/dL; Serum IgG (Adult): 620-1520 mg/dL; IGG INDEX: 17-29 years: 0.32-0.60, 30-39 years: 0.34-0.59, 40-49 years: 0.36-0.56, 50-59 years: 0.33-0.57, 60-150 years: 0.34-0.58.
What causes an increase in cerebrospinal fluid?
It may be due to an increase in the amount of fluid surrounding your brain. For example, there may be an increased amount of the cerebrospinal fluid that naturally cushions your brain or an increase in blood in the brain due to an injury or a ruptured tumor.
What does intrathecal IgG synthesis mean?
Intrathecal IgG synthesis is a key biological feature of multiple sclerosis (MS). When acquired early, it persists over time. A growing body of evidence suggests that intrathecal Ig-secreting cells may be pathogenic either by a direct action of toxic IgG or by locally secreting bystander toxic products.
What is intrathecal IgG?
What causes high protein in CSF?
An abnormal protein level in the CSF suggests a problem in the central nervous system. Increased protein level may be a sign of a tumor, bleeding, nerve inflammation, or injury. A blockage in the flow of spinal fluid can cause the rapid buildup of protein in the lower spinal area.
Where does IgG antibodies come from?
Immunoglobulin G (IgG) is a type of antibody. Representing approximately 75% of serum antibodies in humans, IgG is the most common type of antibody found in blood circulation. IgG molecules are created and released by plasma B cells.
What happens if you have too much cerebrospinal fluid?
Cerebrospinal fluid normally flows through the ventricles and bathes the brain and spinal column. But the pressure of too much cerebrospinal fluid associated with hydrocephalus can damage brain tissues and cause a range of brain function problems.