What should you do if amiodarone is infiltration?
Assess the site of extravasation and the symptoms of the patient. Notify the healthcare provider. Elevate the affected limb to minimize swelling and encourage resorption of the drug via the lymphatic system. Apply dry warm or cold compresses as indicated depending on the drug extravasated.
What is the antidote for amiodarone infiltration?
MANAGEMENT RECOMMENDATIONS
| Vesicant | Antidote recommendations |
|---|---|
| Amiodarone: pH 4.08 43 | Hyaluronidase 13, 56 |
| Arginine: pH 5.6 3 Hypertonicity 193 and local hyperkalemia 194 are additional mechanisms of tissue injury | Hyaluronidase for acid/base vesicants 13 |
| Conivaptan: pH 3.4-3.8 43 | Hyaluronidase 13 |
Is amiodarone IV A vesicant?
Amiodarone IV is a known vesicant. For infusions of longer than 1 hour, concentrations of 2 mg/mL should not be exceeded unless a central venous catheter is used.
Is amiodarone an extravasation?
Due to its acidic property, administration of amiodarone through a peripheral i.v. line has been associated with both phlebitis and extravasation of drug into tissue, and subsequent skin necrosis has been documented.
How is Vanco infiltration treated?
Vancomycin extravasation was successfully managed by utilizing cold compress for the first 24 hours post-extravasation with common gauze open dressings and silver sulfadiazine 1% until the wound was healed.
What happens if IV potassium infiltration?
When left unchecked and untreated, IV infiltration can result in pain, swelling, compartment syndrome, and even amputation of the affected limb.
How is IV infiltration treated?
How is it treated?
- Elevate the site as much as possible to help reduce swelling.
- Apply a warm or cold compress (depending on the fluid) for 30 minutes every 2-3 hours to help reduce swelling and discomfort.
- Medication-If recommended, medicine for extravasations is given within 24 hours for best effect.
How do you give amiodarone injection?
Add 3 mL of Amiodarone HCl Injection (150 mg) to 100 mL D5W (concentration = 1.5 mg/mL). Infuse 100 mL over 10 minutes. Followed by Slow: 360 mg over the NEXT 6 hours (1 mg/min). Add 18 mL of Amiodarone HCl Injection (900 mg) to 500 mL D5W (concentration = 1.8 mg/mL).
How do you give amiodarone IV bolus?
Use of a 0.2 or 0.22 micron filter is recommended for intermittent and continuous infusions.
- Bolus doses: in 100 ml D5W over 10 min (maximum infusion rate 30 mg/min)
- Continuous infusion: in 500 ml D5W (in non PVC bag) over 24 hours.
- Cardiac Arrest: First dose: Give 300 mg (6 mL) IV direct UNDILUTED.
How do you manage infiltration?
Do you put heat or cold on infiltrated IV?
Elevate the site as much as possible to help reduce swelling. Apply a warm or cold compress (depending on the fluid) for 30 minutes every 2-3 hours to help reduce swelling and discomfort.
How dangerous a drug is amiodarone?
Amiodarone may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.
What should I avoid while taking amiodarone?
Amiodarone may be taken with or without food but should be taken at the same way each time. You should avoid consuming grapefruits and grapefruit juice while taking amiodarone. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.
Which are the safer alternatives to amiodarone?
Dronedarone has been viewed as a potential therapeutic alternative for amiodarone because of a lower risk for pulmonary, thyroid, and dermatologic adverse effects. Compared with amiodarone, dronedarone has poor bioavailability and a shorter terminal disposition half-life, which dictates a twice-daily dosing regimen.
What happens if you stop taking amiodarone?
In rare cases, patients who have taken amiodarone for long periods of time and in higher doses may begin to see yellowish halos due to a build-up of small bodies of fat on the eye, known as corneal microdeposits. This side effect reportedly goes away roughly seven months after stopping amiodarone.