Is simvastatin chiral?
Statins have two chiral centers in their molecules, thus they form four enantiomers (3R5R-, 3R5S-, 3S5R- and 3S5S-).
Is simvastatin soluble in water?
Safety profile is also alike among the two types. Although not clinically significant, the study finds that liver enzymes are more commonly elevated with fat-soluble statins (like simvastatin/zocor or atorvastatin/lipitor) then water-soluble ones (pravastatin/pravachol or rosuvastatin/crestor).
Is simvastatin synthetic?
2 Functional properties. Lovastatin, simvastatin and pravastatin are fungal derived inhibitors of HMG-CoA reductase, while atorvastatin, fluvastatin, pitavastatin and rosuvastatin are fully synthetic compounds [4].
What is the active metabolite of simvastatin?
The major active metabolites of simvastatin are β-hydroxyacid metabolite and its 6′-hydroxy, 6′-hydroxymethyl, and 6′-exomethylene derivatives.
Is simvastatin a blood thinner?
The short answer is YES, but very little. Cholesterol lowering drugs, often called “statins” are intended to lower an important component of your total blood cholesterol, the LDL or “low density lipoproteins”.
What class is simvastatin?
Simvastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.
Can you dissolve simvastatin?
For maximum solubility in aqueous buffers, simvastatin should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. Simvastatin has a solubility of approximately 0.5 mg/ml in a 1:1 solution of DMSO:PBS (pH 7.2) using this method.
Are water soluble statins better?
Nevertheless, while some studies, particularly randomised controlled trials, detected superiority of hydrophilic statins regarding to secondary CHD prevention, others reported greater LDL cholesterol reductions with lipophilic statins, which could also account for the more favourable cardiovascular outcomes.
What is the safest statin drug?
Simvastatin and pravastatin had the best safety profile, according to this review. Overall, the researchers found a 9 percent increased risk of type 2 diabetes in people taking statins.
What is simvastatin generic for?
Zocor is available as a generic drug called simvastatin. Lipitor is available as a generic drug called atorvastatin. A generic drug is an exact copy of the active drug in a brand-name medication. The generic is considered to be as safe and effective as the original drug.
Which is better simvastatin or rosuvastatin?
Rarely, both drugs may cause liver, muscle, and kidney damage. Aside from being better at lowering so-called “bad” cholesterol levels in the bloodstream, another advantage to rosuvastatin is that it has far fewer negative interactions with other medications than simvastatin, or most other statins, for that matter.