What is the function of Langerhans?
Langerhans cells (LCs) reside in the epidermis as a dense network of immune system sentinels. These cells determine the appropriate adaptive immune response (inflammation or tolerance) by interpreting the microenvironmental context in which they encounter foreign substances.
Is Langerhans a cancer?
LCH is a form of cancer and often, but not always, requires treatment with chemotherapy. LCH most commonly affects the skin and bones but can involve any organ in the body, including lymph nodes, lungs, liver, spleen, bone marrow or brain.
Are Langerhans part of the immune system?
Langerhans cells (LC) are members of the dendritic cells family, residing in the basal and suprabasal layers of the epidermis and in the epithelia of the respiratory, digestive and urogenital tracts. They specialize in antigen presentation and belong to the skin immune system (SIS).
What do Langerhans cells secrete?
There are five types of cells in the islets of Langerhans: beta cells secrete insulin; alpha cells secrete glucagon; PP cells secrete pancreatic polypeptide; delta cells secrete somatostatin; and epsilon cells secrete ghrelin.
What does Langerhans mean?
noun. : a cell found in the epidermis that functions as an antigen-presenting cell which binds antigen entering through the skin.
Where are Langerhans located?
Langerhans cells are bone marrow-derived, antigen-processing and -presenting cells found mainly in the suprabasal epidermal layers. They are, however, not unique to the epidermis and are found in other squamous epithelia and in the normal dermis.
What cell produces insulin?
When blood glucose levels rise, beta cells in the pancreas normally make the hormone insulin. Insulin triggers cells throughout the body to take up sugar from the blood.
What is Histiocytic?
Histiocytosis is a generic name for a group of syndromes characterized by an abnormal increase in the number of certain immune cells called histiocytes. These include monocytes, macrophages, and dendritic cells.