What is vincamine used for?
Uses. Vincamine is sold in Europe as a prescription medicine for the treatment of primary degenerative and vascular dementia. In the United States, it is permitted to be sold as a dietary supplement when labeled for use in adults for six months or less. Most common preparations are in the sustained release tablet forms …
Is vincamine safe?
As a dietary supplement, vincamine is safe at concentrations up to 60 mg/ml/day for several days (EMEA, 1999), but it was found to inhibit propagation of A549 cells with IC50 of only 309.7 μM.
How long does vinpocetine last?
Vinpocetine might have a small effect on the decline of thinking skills due to dementia or Alzheimer’s, but most studies have lasted 4 months or less. Most of the studies were also published before the current definitions and diagnoses for dementia and Alzheimer’s were established.
Is Huperzine the same as vinpocetine?
Huperzine inhibits AchE, which increases levels of the memory neurotransmitter acetylcholine. Vinpocetine increases cerebral oxygen and concentrations of ATP, and the firing rate of neurons associated with acetylcholine.
What is the role of vinca alkaloid vincamine?
Vincamine is a vinca alkaloid, an alkaloid ester, an organic heteropentacyclic compound, a methyl ester and a hemiaminal. It has a role as an antihypertensive agent, a vasodilator agent and a metabolite. It derives from an eburnamenine.
How is vincamine used in the central nervous system?
Vincamine Dietary Supplements 1617-90-9. Vincamine is used for the prevention and treatment of cerebrovascular insufficiencies and disorders. It has been shown to be pharmacologically active in the central nervous system and in the cardiovascular system but its activity is mainly on the vessels of the brain.
Where does vincamine and vinblastine come from?
Vincamine, vinblastine, and vincristine are very important clinic alkaloids. They are produced naturally by plants: vincamine by Vinca minor, and vinblascine and vincristine by Madagascar periwinkle ( Catharanthus roseus).
How does Linnea produce vincadiformine and vincamine?
In the process used by Linnea, vincamine is produced through two chemical reactions beginning with the catalytic reduction of tabersonine, an alkaloid extract of Voacanga seeds. The resulting product, vincadiformine is oxidized forming vincamine (FDA, 1999; Gerhartz, 1985; Linnea, 2002).
https://www.youtube.com/watch?v=Pb7B3Dj1GQc