How is diltiazem metabolized?
CARDIZEM (diltiazem hydrochloride) is extensively metabolized by the liver and excreted by the kidneys and in bile. As with any drug given over prolonged periods, laboratory parameters of renal and hepatic function should be monitored at regular intervals.
Is there a difference between diltiazem and diltiazem HCl?
These medicines both contain an active ingredient called diltiazem hydrochloride. The difference between these is that Cardizem CD is designed to release the active ingredient slowly so that it works over 24 hours and can be taken once a day (CD stands for “controlled delivery”).
How does diltiazem hydrochloride work?
Diltiazem works by lowering your blood pressure and makes it easier for your heart to pump blood around your body. You can take diltiazem at any time of day. Try to make sure it’s around the same time or times every day. Common side effects include swollen hands, ankles or feet, headaches and constipation.
How long does diltiazem stay in the system?
The peak blood pressure-reducing and blood vessel-widening effects occur three to six hours after oral administration of diltiazem extended-release capsules, and at least 50% of the effect is still present after 24 hours.
Is diltiazem soluble in water?
Solubility: Soluble in water (50mg/ml), methanol or formic acid.
Is diltiazem hard on the liver?
Liver problems warning: This drug can cause mild increases in your liver function enzymes. In rare cases, it may cause sudden harm to your liver. This liver damage often goes away when you stop taking the medication.
Is diltiazem HCl a diuretic?
It may be concluded that diltiazem does not aggravate congestive heart failure through its diuretic action and probably its systemic vasodilating action.
Is diltiazem acidic or basic?
Diltiazem, sold under the brand name Cardizem among others, is a calcium channel blocker medication used to treat high blood pressure, angina, and certain heart arrhythmias….CHEBI:101278 – diltiazem.
| ChEBI Name | diltiazem |
|---|---|
| ChEBI ID | CHEBI:101278 |
What is the molecular weight of diltiazem hydrochloride?
Diltiazem hydrochloride is a white to off-white crystalline powder with a bitter taste. It is soluble in water, methanol and chloroform and has a molecular weight of 450.98. Diltiazem hydrochloride extended-release capsules contain diltiazem hydrochloride in extended-release beads at doses of 120, 180, 240, 300, 360 and 420 mg.
How much Diltiazem is in an extended release capsule?
Diltiazem hydrochloride extended-release capsules contain diltiazem hydrochloride in extended-release beads at doses of 120, 180, 240, 300, 360 and 420 mg.
What is the half life of diltiazem in urine?
Only 2% to 4% of unchanged diltiazem appears in the urine. The plasma elimination half-life of diltiazem is approximately 3.0 to 4.5 hours. Drugs which induce or inhibit hepatic microsomal enzymes may alter diltiazem disposition. Therapeutic blood levels of diltiazem appear to be in the range of 40 to 200 ng/mL.
How does diltiazem block calcium in the blood?
Diltiazem blocks voltage-sensitive calcium channels in the blood vessels, by inhibiting the ion-control gating mechanisms, thereby preventing calcium levels increase by other revenues.